Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint

Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint

Abstract Background Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study is aimed to investigate the regulatory mechanisms of LINC00460 in PC. Methods The tumor and adjacent normal tissues were collected from 73 PC patients. T...

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Bibliographic Details
Main Authors: Jun Yao, Ruoyu Gao, Minghan Luo, Defeng Li, Liliangzi Guo, Zichao Yu, Feng Xiong, Cheng Wei, Benhua Wu, Zhenglei Xu, Dingguo Zhang, Jianyao Wang, Lisheng Wang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cancer Cell International
Subjects:
Pancreatic cancer
LINC00460
miR-503-5p
ANLN
Exosomes
M2 polarization
Online Access:https://doi.org/10.1186/s12935-022-02741-5

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