Coagulation, Microenvironment and Liver Fibrosis
Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead to fibrosis development due to the involvement...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/7/8/85 |
| _version_ | 1797708279433920512 |
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| author | Niccolò Bitto Eleonora Liguori Vincenzo La Mura |
| author_facet | Niccolò Bitto Eleonora Liguori Vincenzo La Mura |
| author_sort | Niccolò Bitto |
| collection | DOAJ |
| description | Fibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead to fibrosis development due to the involvement of several cellular types and biochemical pathways in response to thrombin generation. In the liver, hepatic stellate cells and sinusoidal endothelial cells orchestrate fibrogenic response to chronic damage. Thrombin interacts with these cytotypes mainly through protease-activated receptors (PARs), which are expressed by endothelium, platelets and hepatic stellate cells. This review focuses on the impact of coagulation in liver fibrogenesis, describes receptors and pathways involved and explores the potential antifibrotic properties of drugs active in hemostasis in studies with cells, animal models of liver damage and humans. |
| first_indexed | 2024-03-12T06:20:05Z |
| format | Article |
| id | doaj.art-a745e8ab10964287bc45bbbcbb8769c0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:20:05Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a745e8ab10964287bc45bbbcbb8769c02023-09-03T02:20:07ZengMDPI AGCells2073-44092018-07-01788510.3390/cells7080085cells7080085Coagulation, Microenvironment and Liver FibrosisNiccolò Bitto0Eleonora Liguori1Vincenzo La Mura2Medicina Interna, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Donato, Università Degli Studi di Milano, 20097 San Donato Milanese (MI), ItalyMedicina Interna, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Donato, Università Degli Studi di Milano, 20097 San Donato Milanese (MI), ItalyFondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, UOC Medicina Generale-Emostasi e Trombosi, 20122 Milano, ItalyFibrosis is the main consequence of any kind of chronic liver damage. Coagulation and thrombin generation are crucial in the physiological response to tissue injury; however, the inappropriate and uncontrolled activation of coagulation cascade may lead to fibrosis development due to the involvement of several cellular types and biochemical pathways in response to thrombin generation. In the liver, hepatic stellate cells and sinusoidal endothelial cells orchestrate fibrogenic response to chronic damage. Thrombin interacts with these cytotypes mainly through protease-activated receptors (PARs), which are expressed by endothelium, platelets and hepatic stellate cells. This review focuses on the impact of coagulation in liver fibrogenesis, describes receptors and pathways involved and explores the potential antifibrotic properties of drugs active in hemostasis in studies with cells, animal models of liver damage and humans.http://www.mdpi.com/2073-4409/7/8/85thrombinprotease-activated receptorsendothelial dysfunctionvon Willebrand factorhepatitiscirrhosisanticoagulation |
| spellingShingle | Niccolò Bitto Eleonora Liguori Vincenzo La Mura Coagulation, Microenvironment and Liver Fibrosis Cells thrombin protease-activated receptors endothelial dysfunction von Willebrand factor hepatitis cirrhosis anticoagulation |
| title | Coagulation, Microenvironment and Liver Fibrosis |
| title_full | Coagulation, Microenvironment and Liver Fibrosis |
| title_fullStr | Coagulation, Microenvironment and Liver Fibrosis |
| title_full_unstemmed | Coagulation, Microenvironment and Liver Fibrosis |
| title_short | Coagulation, Microenvironment and Liver Fibrosis |
| title_sort | coagulation microenvironment and liver fibrosis |
| topic | thrombin protease-activated receptors endothelial dysfunction von Willebrand factor hepatitis cirrhosis anticoagulation |
| url | http://www.mdpi.com/2073-4409/7/8/85 |
| work_keys_str_mv | AT niccolobitto coagulationmicroenvironmentandliverfibrosis AT eleonoraliguori coagulationmicroenvironmentandliverfibrosis AT vincenzolamura coagulationmicroenvironmentandliverfibrosis |