Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

<p>Abstract</p> <p>Background</p> <p>Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. The limits on cell divisio...

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Bibliographic Details
Main Authors: Nakamura Asako J, Chiang Y Jeffrey, Hathcock Karen S, Horikawa Izumi, Sedelnikova Olga A, Hodes Richard J, Bonner William M
Format: Article
Language:English
Published: BMC 2008-11-01
Series:Epigenetics & Chromatin
Online Access:http://www.epigeneticsandchromatin.com/content/1/1/6

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