The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study
Background: Anticoagulants (AC) are among the most often prescribed drugs in the world. Data regarding ACs’ effect on the osseointegration of dental implants is lacking. Purpose: The aim of the present retrospective cohort study was to evaluate the effect of anticoagulants (AC) on early implant fail...
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| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/4/186 |
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| author | Liat Chaushu Noa Perez Daniele Botticelli Samuel Porfirio Xavier Roni Kolerman Daya Masri |
| author_facet | Liat Chaushu Noa Perez Daniele Botticelli Samuel Porfirio Xavier Roni Kolerman Daya Masri |
| author_sort | Liat Chaushu |
| collection | DOAJ |
| description | Background: Anticoagulants (AC) are among the most often prescribed drugs in the world. Data regarding ACs’ effect on the osseointegration of dental implants is lacking. Purpose: The aim of the present retrospective cohort study was to evaluate the effect of anticoagulants (AC) on early implant failure (EIF). The null hypothesis was that the use of AC increases the incidence of EIF. Materials and Methods: The research included 687 patients who underwent 2971 dental implant placements in the department of oral and maxillofacial surgery in Rabin medical center, Beilinson hospital, by specialists in oral and maxillofacial surgery. The study group comprised 173 (25.2%) patients and 708 (23.8%) implants using AC. The rest of the cohort served as a control. A structured form was used to collect data at patient and implant level. EIF was defined as implant failure within a period of up to 12 months from loading. EIF was the primary outcome parameter. A logistic regression model was used to predict EIF. Results: Implants placed in individuals ≥ 80 (odds ratio (OR) = 0.34, <i>p</i> = 0.05), and ASA 2/3 vs. ASA 1 individuals (OR = 0.30, <i>p</i> = 0.02/OR = 0.33, <i>p</i> = 0.03, respectively) had decreased odds of EIF, and implants in those using anticoagulants (OR = 2.64, <i>p</i> = 0.01) had increased odds of EIF. At the patient level, the odds of EIF in ASA 3 (OR = 0.53, <i>p</i> = 0.02) and IHD (OR = 0.40, <i>p</i> = 0.02) individuals decreased. In AF/VF (OR = 2.95, <i>p</i> = 0.01) individuals, EIF odds increased. Conclusions: Within the limitations of the present study, the use of AC is significantly associated with an increased likelihood of EIF: the OR was 2.64. Future research is required to validate and examine the prospective impact of AC on the osseointegration phenomena. |
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| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T04:53:12Z |
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| spelling | doaj.art-a74b56af7e694820a730ea3dc68aeddf2023-11-17T19:52:55ZengMDPI AGJournal of Functional Biomaterials2079-49832023-03-0114418610.3390/jfb14040186The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort StudyLiat Chaushu0Noa Perez1Daniele Botticelli2Samuel Porfirio Xavier3Roni Kolerman4Daya Masri5Department of Periodontology and Implant Dentistry, The Maurice and Gabriela Goldschleger School of Dentistry, Tel Aviv University, Tel Aviv 6934206, IsraelDepartment of Periodontology and Implant Dentistry, The Maurice and Gabriela Goldschleger School of Dentistry, Tel Aviv University, Tel Aviv 6934206, IsraelARDEC Academy, Viale Giovanni Pascoli 67, 47923 Rimini, ItalyDepartment of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste-11 (N-11), Ribeirão Preto 14040-904, BrazilDepartment of Periodontology and Implant Dentistry, The Maurice and Gabriela Goldschleger School of Dentistry, Tel Aviv University, Tel Aviv 6934206, IsraelDepartment of Oral and Maxillofacial Surgery, Rabin Medical Center, Beilinson Campus, Petah Tiqwa 49414, IsraelBackground: Anticoagulants (AC) are among the most often prescribed drugs in the world. Data regarding ACs’ effect on the osseointegration of dental implants is lacking. Purpose: The aim of the present retrospective cohort study was to evaluate the effect of anticoagulants (AC) on early implant failure (EIF). The null hypothesis was that the use of AC increases the incidence of EIF. Materials and Methods: The research included 687 patients who underwent 2971 dental implant placements in the department of oral and maxillofacial surgery in Rabin medical center, Beilinson hospital, by specialists in oral and maxillofacial surgery. The study group comprised 173 (25.2%) patients and 708 (23.8%) implants using AC. The rest of the cohort served as a control. A structured form was used to collect data at patient and implant level. EIF was defined as implant failure within a period of up to 12 months from loading. EIF was the primary outcome parameter. A logistic regression model was used to predict EIF. Results: Implants placed in individuals ≥ 80 (odds ratio (OR) = 0.34, <i>p</i> = 0.05), and ASA 2/3 vs. ASA 1 individuals (OR = 0.30, <i>p</i> = 0.02/OR = 0.33, <i>p</i> = 0.03, respectively) had decreased odds of EIF, and implants in those using anticoagulants (OR = 2.64, <i>p</i> = 0.01) had increased odds of EIF. At the patient level, the odds of EIF in ASA 3 (OR = 0.53, <i>p</i> = 0.02) and IHD (OR = 0.40, <i>p</i> = 0.02) individuals decreased. In AF/VF (OR = 2.95, <i>p</i> = 0.01) individuals, EIF odds increased. Conclusions: Within the limitations of the present study, the use of AC is significantly associated with an increased likelihood of EIF: the OR was 2.64. Future research is required to validate and examine the prospective impact of AC on the osseointegration phenomena.https://www.mdpi.com/2079-4983/14/4/186anticoagulantsdental implantearly implant failure |
| spellingShingle | Liat Chaushu Noa Perez Daniele Botticelli Samuel Porfirio Xavier Roni Kolerman Daya Masri The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study Journal of Functional Biomaterials anticoagulants dental implant early implant failure |
| title | The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study |
| title_full | The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study |
| title_fullStr | The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study |
| title_full_unstemmed | The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study |
| title_short | The Effect of Anticoagulants on Early Implant Failure: A Retrospective Cohort Study |
| title_sort | effect of anticoagulants on early implant failure a retrospective cohort study |
| topic | anticoagulants dental implant early implant failure |
| url | https://www.mdpi.com/2079-4983/14/4/186 |
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