Role of endothelial CXCR4 in the development of aortic valve stenosis

Role of endothelial CXCR4 in the development of aortic valve stenosis

BackgroundCXCL12/CXCR4 signaling is essential in cardiac development and repair, however, its contribution to aortic valve stenosis (AVS) remains unclear. In this study, we tested the role of endothelial CXCR4 on the development of AVS.Materials and methodsWe generated CXCR4 endothelial cell-specifi...

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Bibliographic Details
Main Authors: Anna Winnicki, James Gadd, Vahagn Ohanyan, Gilbert Hernandez, Yang Wang, Molly Enrick, Hannah McKillen, Matthew Kiedrowski, Dipan Kundu, Karlina Kegecik, Marc Penn, William M. Chilian, Liya Yin, Feng Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
CXCR4
aortic stenosis
aortic valve stenosis
cardiac hypertrophy
endothelium
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.971321/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.971321/full

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