Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy
As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has been compromised, and in spite of introducing various kinds of anticancer drugs, cancer eradication with chemotherapy is still impossible. Chemotherapy drugs have been beneficial in improving the prognosis of ca...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523323002243 |
| _version_ | 1797422654219616256 |
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| author | Mohsen Bagheri Mohammad Arad Zandieh Mahshid Daryab Seyedeh Setareh Samaei Sarah Gholami Parham Rahmanian Sadaf Dezfulian Mahsa Eary Aryan Rezaee Romina Rajabi Ramin Khorrami Shokooh Salimimoghadam Peng Hu Mohsen Rashidi Alireza Khodaei Ardakan Yavuz Nuri Ertas Kiavash Hushmandi |
| author_facet | Mohsen Bagheri Mohammad Arad Zandieh Mahshid Daryab Seyedeh Setareh Samaei Sarah Gholami Parham Rahmanian Sadaf Dezfulian Mahsa Eary Aryan Rezaee Romina Rajabi Ramin Khorrami Shokooh Salimimoghadam Peng Hu Mohsen Rashidi Alireza Khodaei Ardakan Yavuz Nuri Ertas Kiavash Hushmandi |
| author_sort | Mohsen Bagheri |
| collection | DOAJ |
| description | As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has been compromised, and in spite of introducing various kinds of anticancer drugs, cancer eradication with chemotherapy is still impossible. Chemotherapy drugs have been beneficial in improving the prognosis of cancer patients, but after resistance emerged, their potential disappeared. Oxaliplatin (OXA) efficacy in tumor suppression has been compromised by resistance. Due to the dysregulation of pathways and mechanisms in OXA resistance, it is suggested to develop novel strategies for overcoming drug resistance. The targeted delivery of OXA by nanostructures is described here. The targeted delivery of OXA in cancer can be mediated by polymeric, metal, lipid and carbon nanostructures. The advantageous of these nanocarriers is that they enhance the accumulation of OXA in tumor and promote its cytotoxicity. Moreover, (nano)platforms mediate the co-delivery of OXA with drugs and genes in synergistic cancer therapy, overcoming OXA resistance and improving insights in cancer patient treatment in the future. Moreover, smart nanostructures, including pH-, redox-, light-, and thermo-sensitive nanostructures, have been designed for OXA delivery and cancer therapy. The application of nanoparticle-mediated phototherapy can increase OXA's potential in cancer suppression. All of these subjects and their clinical implications are discussed in the current review. |
| first_indexed | 2024-03-09T07:35:31Z |
| format | Article |
| id | doaj.art-a74ebb09d60d4f73aee27240325c1ccd |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-03-09T07:35:31Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-a74ebb09d60d4f73aee27240325c1ccd2023-12-03T05:40:31ZengElsevierTranslational Oncology1936-52332024-01-0139101838Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapyMohsen Bagheri0Mohammad Arad Zandieh1Mahshid Daryab2Seyedeh Setareh Samaei3Sarah Gholami4Parham Rahmanian5Sadaf Dezfulian6Mahsa Eary7Aryan Rezaee8Romina Rajabi9Ramin Khorrami10Shokooh Salimimoghadam11Peng Hu12Mohsen Rashidi13Alireza Khodaei Ardakan14Yavuz Nuri Ertas15Kiavash Hushmandi16Radiology Resident, Tehran University of Medical Sciences, Tehran, IranDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranYoung Researcher and Elite Club, Babol Branch, Islamic Azad University, Babol, IranFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranStudent Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, IranFaculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Emergency, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, ChinaDepartment Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Corresponding author at: Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran; Corresponding authors.Department of Biomedical Engineering, Erciyes University, Kayseri, Turkey; ERNAM–Nanotechnology Research and Application Center, Erciyes University, Kayseri, TurkeyDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran; Corresponding authors.As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has been compromised, and in spite of introducing various kinds of anticancer drugs, cancer eradication with chemotherapy is still impossible. Chemotherapy drugs have been beneficial in improving the prognosis of cancer patients, but after resistance emerged, their potential disappeared. Oxaliplatin (OXA) efficacy in tumor suppression has been compromised by resistance. Due to the dysregulation of pathways and mechanisms in OXA resistance, it is suggested to develop novel strategies for overcoming drug resistance. The targeted delivery of OXA by nanostructures is described here. The targeted delivery of OXA in cancer can be mediated by polymeric, metal, lipid and carbon nanostructures. The advantageous of these nanocarriers is that they enhance the accumulation of OXA in tumor and promote its cytotoxicity. Moreover, (nano)platforms mediate the co-delivery of OXA with drugs and genes in synergistic cancer therapy, overcoming OXA resistance and improving insights in cancer patient treatment in the future. Moreover, smart nanostructures, including pH-, redox-, light-, and thermo-sensitive nanostructures, have been designed for OXA delivery and cancer therapy. The application of nanoparticle-mediated phototherapy can increase OXA's potential in cancer suppression. All of these subjects and their clinical implications are discussed in the current review.http://www.sciencedirect.com/science/article/pii/S1936523323002243OxaliplatinTargeted deliveryChemoresistanceSynergistic cancer therapyGene and drug delivery |
| spellingShingle | Mohsen Bagheri Mohammad Arad Zandieh Mahshid Daryab Seyedeh Setareh Samaei Sarah Gholami Parham Rahmanian Sadaf Dezfulian Mahsa Eary Aryan Rezaee Romina Rajabi Ramin Khorrami Shokooh Salimimoghadam Peng Hu Mohsen Rashidi Alireza Khodaei Ardakan Yavuz Nuri Ertas Kiavash Hushmandi Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy Translational Oncology Oxaliplatin Targeted delivery Chemoresistance Synergistic cancer therapy Gene and drug delivery |
| title | Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy |
| title_full | Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy |
| title_fullStr | Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy |
| title_full_unstemmed | Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy |
| title_short | Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy |
| title_sort | nanostructures for site specific delivery of oxaliplatin cancer therapy versatile nanoplatforms in synergistic cancer therapy |
| topic | Oxaliplatin Targeted delivery Chemoresistance Synergistic cancer therapy Gene and drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S1936523323002243 |
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