Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections
To date, curative resection is the only chance for cure for patients suffering from pancreatic ductal adenoacarcinoma (PDAC). Despite low reported rates of microscopic tumor infiltration (R1) in most studies, tumor recurrence is a common finding in patients with PDAC and contributes to extremely low...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/2/4/2001/ |
| _version_ | 1797705866567221248 |
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| author | Irene Esposito Anna Melissa Schlitter |
| author_facet | Irene Esposito Anna Melissa Schlitter |
| author_sort | Irene Esposito |
| collection | DOAJ |
| description | To date, curative resection is the only chance for cure for patients suffering from pancreatic ductal adenoacarcinoma (PDAC). Despite low reported rates of microscopic tumor infiltration (R1) in most studies, tumor recurrence is a common finding in patients with PDAC and contributes to extremely low long-term survival rates. Lack of international definition of resection margins and of standardized protocols for pathological examination lead to high variation in reported R1 rates. Here we review recent studies supporting the hypothesis that R1 rates are highly underestimated in certain studies and that a microscopic tumor clearance of at least 1 mm is required to confirm radicality and to serve as a reliable prognostic and predictive factor. |
| first_indexed | 2024-03-12T05:43:43Z |
| format | Article |
| id | doaj.art-a74f115f896240668a8376bc1d149941 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:43:43Z |
| publishDate | 2010-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a74f115f896240668a8376bc1d1499412023-09-03T05:50:12ZengMDPI AGCancers2072-66942010-11-01242001201010.3390/cancers2042001Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer ResectionsIrene EspositoAnna Melissa SchlitterTo date, curative resection is the only chance for cure for patients suffering from pancreatic ductal adenoacarcinoma (PDAC). Despite low reported rates of microscopic tumor infiltration (R1) in most studies, tumor recurrence is a common finding in patients with PDAC and contributes to extremely low long-term survival rates. Lack of international definition of resection margins and of standardized protocols for pathological examination lead to high variation in reported R1 rates. Here we review recent studies supporting the hypothesis that R1 rates are highly underestimated in certain studies and that a microscopic tumor clearance of at least 1 mm is required to confirm radicality and to serve as a reliable prognostic and predictive factor.http://www.mdpi.com/2072-6694/2/4/2001/pancreatic cancerresection marginR1definition of resection statuspathological standardization |
| spellingShingle | Irene Esposito Anna Melissa Schlitter Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections Cancers pancreatic cancer resection margin R1 definition of resection status pathological standardization |
| title | Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections |
| title_full | Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections |
| title_fullStr | Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections |
| title_full_unstemmed | Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections |
| title_short | Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections |
| title_sort | definition of microscopic tumor clearance r0 in pancreatic cancer resections |
| topic | pancreatic cancer resection margin R1 definition of resection status pathological standardization |
| url | http://www.mdpi.com/2072-6694/2/4/2001/ |
| work_keys_str_mv | AT ireneesposito definitionofmicroscopictumorclearancer0inpancreaticcancerresections AT annamelissaschlitter definitionofmicroscopictumorclearancer0inpancreaticcancerresections |