Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

ABSTRACT Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular mechanisms underlying HIV-1 latency are complex where the possible link between integration and transcri...

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Bibliographic Details
Main Authors: Julie Janssens, Flore De Wit, Nagma Parveen, Zeger Debyser
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
HIV-1
LEDGF/p75
LEDGINs
integration site selection
single-cell HIV-1 imaging
Online Access:https://journals.asm.org/doi/10.1128/mbio.00007-22

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