Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia
<p><strong>Introduction and purpose:</strong> Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness, nonrestorative sleep, anxiety, depression and cognitiv...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2020-09-01
|
| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/31323 |
| _version_ | 1818911532844580864 |
|---|---|
| author | Małgorzata Drozd Magdalena Marzęda Agnieszka Blicharz Jakub Czarnota Halina Piecewicz-Szczęsna |
| author_facet | Małgorzata Drozd Magdalena Marzęda Agnieszka Blicharz Jakub Czarnota Halina Piecewicz-Szczęsna |
| author_sort | Małgorzata Drozd |
| collection | DOAJ |
| description | <p><strong>Introduction and purpose:</strong> Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness, nonrestorative sleep, anxiety, depression and cognitive dysfunction. The etiology of fibromyalgia remains unclear and has been the subject of debate and scientific investigation. The aim of this article was to collect and analyse current and new information on the etiology of fibromyalgia and present the most popular hypotheses.</p><p><strong>Brief description of the state of knowledge:</strong> Pathogenesis of fibromyalgia is multifactorial. Genetic factors, in addition to environmental factors, such as psychical stress and various types of infection, are considered to be the triggers of the disease. Central sensitization became a commonly accepted hypothesis of the fibromyalgia’s pathogenesis. However, the newest finding of small fiber neuropathy in patients with fibromyalgia supports another hypothesis, in which the disease is presented as stress-related dysautonomia with neuropathic pain features.</p><p><strong>Conclusions: </strong>Understanding the pathogenesis of fibromyalgia is essential to provide the best care to the patients with fibromyalgia. Although there are multiple evidence for central sensitization hypothesis, new findings continue to emerge and question commonly accepted paradigm. Despite numerous findings on etiology of fibromyalgia, more studies are needed.</p> |
| first_indexed | 2024-12-19T23:00:12Z |
| format | Article |
| id | doaj.art-a750bd8611fa432a8a53b28ac51d4030 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-12-19T23:00:12Z |
| publishDate | 2020-09-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-a750bd8611fa432a8a53b28ac51d40302022-12-21T20:02:31ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062020-09-0110933834410.12775/JEHS.2020.10.09.03825265Unclear etiology and current hypotheses of the pathogenesis of fibromyalgiaMałgorzata Drozd0Magdalena Marzęda1Agnieszka Blicharz2Jakub Czarnota3Halina Piecewicz-Szczęsna4Student Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of LublinStudent Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of LublinStudent Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of LublinStudent Research Circle at the Department of Epidemiology and Clinical Research Methodology, Medical University of LublinDepartment of Epidemiology and Clinical Research Methodology, Medical University of Lublin<p><strong>Introduction and purpose:</strong> Fibromyalgia is a chronic condition affecting almost 2% of the general population, mostly women. The main symptoms are chronic diffuse musculoskeletal pain or stiffness, tiredness, nonrestorative sleep, anxiety, depression and cognitive dysfunction. The etiology of fibromyalgia remains unclear and has been the subject of debate and scientific investigation. The aim of this article was to collect and analyse current and new information on the etiology of fibromyalgia and present the most popular hypotheses.</p><p><strong>Brief description of the state of knowledge:</strong> Pathogenesis of fibromyalgia is multifactorial. Genetic factors, in addition to environmental factors, such as psychical stress and various types of infection, are considered to be the triggers of the disease. Central sensitization became a commonly accepted hypothesis of the fibromyalgia’s pathogenesis. However, the newest finding of small fiber neuropathy in patients with fibromyalgia supports another hypothesis, in which the disease is presented as stress-related dysautonomia with neuropathic pain features.</p><p><strong>Conclusions: </strong>Understanding the pathogenesis of fibromyalgia is essential to provide the best care to the patients with fibromyalgia. Although there are multiple evidence for central sensitization hypothesis, new findings continue to emerge and question commonly accepted paradigm. Despite numerous findings on etiology of fibromyalgia, more studies are needed.</p>https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/31323fibromyalgiaetiologyphysiopathologycentral sensitizationdysautonomiasmall fiber neuropathy |
| spellingShingle | Małgorzata Drozd Magdalena Marzęda Agnieszka Blicharz Jakub Czarnota Halina Piecewicz-Szczęsna Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia Journal of Education, Health and Sport fibromyalgia etiology physiopathology central sensitization dysautonomia small fiber neuropathy |
| title | Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| title_full | Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| title_fullStr | Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| title_full_unstemmed | Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| title_short | Unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| title_sort | unclear etiology and current hypotheses of the pathogenesis of fibromyalgia |
| topic | fibromyalgia etiology physiopathology central sensitization dysautonomia small fiber neuropathy |
| url | https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/31323 |
| work_keys_str_mv | AT małgorzatadrozd unclearetiologyandcurrenthypothesesofthepathogenesisoffibromyalgia AT magdalenamarzeda unclearetiologyandcurrenthypothesesofthepathogenesisoffibromyalgia AT agnieszkablicharz unclearetiologyandcurrenthypothesesofthepathogenesisoffibromyalgia AT jakubczarnota unclearetiologyandcurrenthypothesesofthepathogenesisoffibromyalgia AT halinapiecewiczszczesna unclearetiologyandcurrenthypothesesofthepathogenesisoffibromyalgia |