Therapeutic Applications of Programmable DNA Nanostructures
Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-666X/13/2/315 |
| _version_ | 1797477939539869696 |
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| author | Seaim Lwin Aye Yusuke Sato |
| author_facet | Seaim Lwin Aye Yusuke Sato |
| author_sort | Seaim Lwin Aye |
| collection | DOAJ |
| description | Deoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of DNA nanostructures allows the precise engineering of DNA nanocarriers with controllable shapes, sizes, surface chemistries, and functions to deliver therapeutic and functional payloads to target cells with higher efficiency and enhanced specificity. Programmability and control over design also allow the creation of dynamic devices, such as DNA nanorobots, that can react to external stimuli and execute programmed tasks. This review focuses on the current findings and progress in the field, mainly on the employment of DNA nanostructures such as DNA origami nanorobots, DNA nanotubes, DNA tetrahedra, DNA boxes, and DNA nanoflowers in the biomedical field for therapeutic purposes. We will also discuss the fate of DNA nanostructures in living cells, the major obstacles to overcome, that is, the stability of DNA nanostructures in biomedical applications, and the opportunities for DNA nanostructure-based drug delivery in the future. |
| first_indexed | 2024-03-09T21:24:53Z |
| format | Article |
| id | doaj.art-a75269bc75ec47df8c8e08e54e98e2b3 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T21:24:53Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a75269bc75ec47df8c8e08e54e98e2b32023-11-23T21:11:58ZengMDPI AGMicromachines2072-666X2022-02-0113231510.3390/mi13020315Therapeutic Applications of Programmable DNA NanostructuresSeaim Lwin Aye0Yusuke Sato1Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, JapanFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai 980-8578, JapanDeoxyribonucleic acid (DNA) nanotechnology, a frontier in biomedical engineering, is an emerging field that has enabled the engineering of molecular-scale DNA materials with applications in biomedicine such as bioimaging, biodetection, and drug delivery over the past decades. The programmability of DNA nanostructures allows the precise engineering of DNA nanocarriers with controllable shapes, sizes, surface chemistries, and functions to deliver therapeutic and functional payloads to target cells with higher efficiency and enhanced specificity. Programmability and control over design also allow the creation of dynamic devices, such as DNA nanorobots, that can react to external stimuli and execute programmed tasks. This review focuses on the current findings and progress in the field, mainly on the employment of DNA nanostructures such as DNA origami nanorobots, DNA nanotubes, DNA tetrahedra, DNA boxes, and DNA nanoflowers in the biomedical field for therapeutic purposes. We will also discuss the fate of DNA nanostructures in living cells, the major obstacles to overcome, that is, the stability of DNA nanostructures in biomedical applications, and the opportunities for DNA nanostructure-based drug delivery in the future.https://www.mdpi.com/2072-666X/13/2/315DNA nanostructureDNA nanorobotsDNA nanotechnologydrug deliverycellular targetingcell membrane |
| spellingShingle | Seaim Lwin Aye Yusuke Sato Therapeutic Applications of Programmable DNA Nanostructures Micromachines DNA nanostructure DNA nanorobots DNA nanotechnology drug delivery cellular targeting cell membrane |
| title | Therapeutic Applications of Programmable DNA Nanostructures |
| title_full | Therapeutic Applications of Programmable DNA Nanostructures |
| title_fullStr | Therapeutic Applications of Programmable DNA Nanostructures |
| title_full_unstemmed | Therapeutic Applications of Programmable DNA Nanostructures |
| title_short | Therapeutic Applications of Programmable DNA Nanostructures |
| title_sort | therapeutic applications of programmable dna nanostructures |
| topic | DNA nanostructure DNA nanorobots DNA nanotechnology drug delivery cellular targeting cell membrane |
| url | https://www.mdpi.com/2072-666X/13/2/315 |
| work_keys_str_mv | AT seaimlwinaye therapeuticapplicationsofprogrammablednananostructures AT yusukesato therapeuticapplicationsofprogrammablednananostructures |