Serum Adenosine Deaminase Activity and Its Correlation with Glycated Haemoglobin Levels in Patients of Type 2 Diabetes Mellitus
Background: Adenosine deaminase (ADA) is suggested to be an important enzyme for modulating the bioactivity of insulin, but its clinical significance in Type 2 diabetes mellitus (Type 2 DM) is not yet characterized. The present study was undertaken to evaluate serum ADA activity and serum uric a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2012-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2030/24-%203926.A.pdf |
| Summary: | Background: Adenosine deaminase (ADA) is suggested to be
an important enzyme for modulating the bioactivity of insulin,
but its clinical significance in Type 2 diabetes mellitus (Type 2
DM) is not yet characterized. The present study was undertaken
to evaluate serum ADA activity and serum uric acid levels in
patients of Type 2 DM.
Material and Method: It is a of case control study. The subjects
included in this study were divided into 3 groups. Group A
consisted of 60 normal healthy individuals who served as
controls with no history of DM. Group B consisted of 60 patients
of Type 2 Diabetes Mellitus both males & females in the age
group of 40-65 years on oral hypoglycaemic drugs with HbA1c
<7%. Group C consisted of 60 patients of Type 2 Diabetes
Mellitus both males & females in the age group of 40-65 years
on oral hypoglycaemic drugs with HbA1c
>7 %. Serum levels of
fasting blood sugar, HbA1c
, ADA and uric acid were estimated in
all the subjects under study.
Results: All the three parameters, FBS, HbA1c
and ADA levels
were found to be increased in the patients of Type 2 DM as
compared to controls. The mean serum uric acid levels showed
a bell shaped relation with glycaemic control.
Conclusion: From the present study, it is concluded that there
is an increase in serum ADA levels with increase in HbA1c
levels.
It was found that the serum uric acid levels increased with
moderately increasing levels of HbA1c
<7% and then decreased
with further increasing levels of HbA1c
>7% (a bell-shaped
relation). |
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| ISSN: | 2249-782X 0973-709X |