Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study
Xiaowei Deng,1 Cun-hua Yuan,1 De Chang2 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China Background: SERPINA1 gene has been implicated in the pathogenesis of chronic obstru...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-01-01
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| Series: | International Journal of COPD |
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| Online Access: | https://www.dovepress.com/interactions-between-single-nucleotide-polymorphism-of-serpina1-gene-a-peer-reviewed-article-COPD |
| _version_ | 1818546315420762112 |
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| author | Deng XW Yuan CH Chang D |
| author_facet | Deng XW Yuan CH Chang D |
| author_sort | Deng XW |
| collection | DOAJ |
| description | Xiaowei Deng,1 Cun-hua Yuan,1 De Chang2 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China Background: SERPINA1 gene has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), while smoking is a known risk factor for COPD. Little is known on the effect of SERPINA1 gene and its interaction with smoking in the Chinese population. In this study, the effect of SERPINA1 gene polymorphisms on COPD risk and its interaction with smoking status has been investigated.Method: A total of 120 COPD patients and 481 healthy controls were recruited at The Armed Police Corps Hospital. Data on demographic variables, smoking status, history of occupational dust exposure, and allergies were collected. Genotyping for single nucleotide polymorphism’s (SNP) rs1243160, rs2854254, and rs8004738 was performed in all participants.Results: SNP rs8004738 genotype was associated with a significantly higher risk for COPD (odds ratio (OR) =1.835, 95% confidence interval (CI): 1.002–3.360), whereas SNPs rs1243160 and rs2854254 did not exhibit such an association. Smoking habit also significantly increased the risk for COPD (OR =2.306, 95% CI: 1.537–3.459). On stepwise logistic regression analysis, advanced age, smoking, and SNP rs8004738 variant were associated with increased risk for COPD, while female gender and higher educational status decreased the risk. On additive interaction analysis, a significant interactive effect of SNP rs8004738 and smoking was observed in this population (relative excess risk due to interaction =0.478; attributable proportion due to interaction (AP) =0.123; S=1.197).Conclusion: SNP rs8004738 of SERPINA1 gene significantly interacted with smoking status and was associated with a higher risk for COPD in the Chinese population. Keywords: chronic obstructive pulmonary disease (COPD), single nucleotide polymorphism (SNP), smoking, SERPINA1 polymorphism |
| first_indexed | 2024-12-12T07:51:33Z |
| format | Article |
| id | doaj.art-a7532d5975f54669899546ed78b81de4 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-12T07:51:33Z |
| publishDate | 2017-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-a7532d5975f54669899546ed78b81de42022-12-22T00:32:26ZengDove Medical PressInternational Journal of COPD1178-20052017-01-01Volume 1225926530805Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control studyDeng XWYuan CHChang DXiaowei Deng,1 Cun-hua Yuan,1 De Chang2 1Health Medical Center, 2Department of Respiratory Medicine, General Hospital of Chinese People’s Armed Police Forces, Beijing, People’s Republic of China Background: SERPINA1 gene has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), while smoking is a known risk factor for COPD. Little is known on the effect of SERPINA1 gene and its interaction with smoking in the Chinese population. In this study, the effect of SERPINA1 gene polymorphisms on COPD risk and its interaction with smoking status has been investigated.Method: A total of 120 COPD patients and 481 healthy controls were recruited at The Armed Police Corps Hospital. Data on demographic variables, smoking status, history of occupational dust exposure, and allergies were collected. Genotyping for single nucleotide polymorphism’s (SNP) rs1243160, rs2854254, and rs8004738 was performed in all participants.Results: SNP rs8004738 genotype was associated with a significantly higher risk for COPD (odds ratio (OR) =1.835, 95% confidence interval (CI): 1.002–3.360), whereas SNPs rs1243160 and rs2854254 did not exhibit such an association. Smoking habit also significantly increased the risk for COPD (OR =2.306, 95% CI: 1.537–3.459). On stepwise logistic regression analysis, advanced age, smoking, and SNP rs8004738 variant were associated with increased risk for COPD, while female gender and higher educational status decreased the risk. On additive interaction analysis, a significant interactive effect of SNP rs8004738 and smoking was observed in this population (relative excess risk due to interaction =0.478; attributable proportion due to interaction (AP) =0.123; S=1.197).Conclusion: SNP rs8004738 of SERPINA1 gene significantly interacted with smoking status and was associated with a higher risk for COPD in the Chinese population. Keywords: chronic obstructive pulmonary disease (COPD), single nucleotide polymorphism (SNP), smoking, SERPINA1 polymorphism https://www.dovepress.com/interactions-between-single-nucleotide-polymorphism-of-serpina1-gene-a-peer-reviewed-article-COPDChronic obstructive pulmonary disease (COPD)Single nucleotide polymorphism (SNP)SmokingSERPINA1polymorphism |
| spellingShingle | Deng XW Yuan CH Chang D Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study International Journal of COPD Chronic obstructive pulmonary disease (COPD) Single nucleotide polymorphism (SNP) Smoking SERPINA1polymorphism |
| title | Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study |
| title_full | Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study |
| title_fullStr | Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study |
| title_full_unstemmed | Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study |
| title_short | Interactions between single nucleotide polymorphism of SERPINA1 gene and smoking in association with COPD: a case–control study |
| title_sort | interactions between single nucleotide polymorphism of serpina1 gene and smoking in association with copd a case ndash control study |
| topic | Chronic obstructive pulmonary disease (COPD) Single nucleotide polymorphism (SNP) Smoking SERPINA1polymorphism |
| url | https://www.dovepress.com/interactions-between-single-nucleotide-polymorphism-of-serpina1-gene-a-peer-reviewed-article-COPD |
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