High risk HPV testing for cervical cancer screening in a Puerto Rican population
The Human Papillomavirus (HPV) causes cervical cancer, the fourth most common cause of death in women in the United States (US). Several major screening clinical trials have demonstrated that high risk HPV (HR-HPV) DNA primary screen is more sensitive at determining the risk of cervical intraepithel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578923001054 |
| _version_ | 1797753975333715968 |
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| author | Erik A. Gustafson Juan C. Santa Rosario Carlos Rios-Bedoya Mariano de Socarraz |
| author_facet | Erik A. Gustafson Juan C. Santa Rosario Carlos Rios-Bedoya Mariano de Socarraz |
| author_sort | Erik A. Gustafson |
| collection | DOAJ |
| description | The Human Papillomavirus (HPV) causes cervical cancer, the fourth most common cause of death in women in the United States (US). Several major screening clinical trials have demonstrated that high risk HPV (HR-HPV) DNA primary screen is more sensitive at determining the risk of cervical intraepithelial neoplasia level 3 or higher (CIN ≥ 3) than cytology alone and is similar to co-testing. In this cross-sectional study, we characterized a Hispanic population of 18,052 women ages 21–70 years with HR-HPV DNA testing and cytology to determine the prevalence of HR-HPV in the population and determine the likelihood of high grade squamous intraepithelial lesion (HSIL). We also compared cytology, HR-HPV DNA testing, and co-testing strategies to determine sensitivity, specificity, positive predictive value, and negative predictive value for HSIL in cervical biopsies. Results show that HR-HPV had a slightly higher sensitivity (94.2% vs 92.3%) compared to cytology for all high-grade disease (CIN2/3). |
| first_indexed | 2024-03-12T17:26:46Z |
| format | Article |
| id | doaj.art-a7534361c9ab476aafbfb797a66d44c8 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-03-12T17:26:46Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-a7534361c9ab476aafbfb797a66d44c82023-08-05T05:16:14ZengElsevierGynecologic Oncology Reports2352-57892023-08-0148101236High risk HPV testing for cervical cancer screening in a Puerto Rican populationErik A. Gustafson0Juan C. Santa Rosario1Carlos Rios-Bedoya2Mariano de Socarraz3CorePlus Servicios Clínicos y Patológicos LLC, Carolina, PR 00983, United States; Corresponding author at: Plazoleta La Cerámica, Suite 2-6 Ave. Sánchez Vilella, Esq. PR-190, Carolina, PR 00983, United States.CorePlus Servicios Clínicos y Patológicos LLC, Carolina, PR 00983, United StatesMcLaren Health Care Corporation, Graduate Medical Education, Grand Blanc, MI 48439, United StatesCorePlus Servicios Clínicos y Patológicos LLC, Carolina, PR 00983, United StatesThe Human Papillomavirus (HPV) causes cervical cancer, the fourth most common cause of death in women in the United States (US). Several major screening clinical trials have demonstrated that high risk HPV (HR-HPV) DNA primary screen is more sensitive at determining the risk of cervical intraepithelial neoplasia level 3 or higher (CIN ≥ 3) than cytology alone and is similar to co-testing. In this cross-sectional study, we characterized a Hispanic population of 18,052 women ages 21–70 years with HR-HPV DNA testing and cytology to determine the prevalence of HR-HPV in the population and determine the likelihood of high grade squamous intraepithelial lesion (HSIL). We also compared cytology, HR-HPV DNA testing, and co-testing strategies to determine sensitivity, specificity, positive predictive value, and negative predictive value for HSIL in cervical biopsies. Results show that HR-HPV had a slightly higher sensitivity (94.2% vs 92.3%) compared to cytology for all high-grade disease (CIN2/3).http://www.sciencedirect.com/science/article/pii/S2352578923001054Cervical cancer screeningHigh Risk Human PapillomavirusCytologyCo-testingHigh grade squamous intraepithelial lesion (HSIL), Puerto Rico |
| spellingShingle | Erik A. Gustafson Juan C. Santa Rosario Carlos Rios-Bedoya Mariano de Socarraz High risk HPV testing for cervical cancer screening in a Puerto Rican population Gynecologic Oncology Reports Cervical cancer screening High Risk Human Papillomavirus Cytology Co-testing High grade squamous intraepithelial lesion (HSIL), Puerto Rico |
| title | High risk HPV testing for cervical cancer screening in a Puerto Rican population |
| title_full | High risk HPV testing for cervical cancer screening in a Puerto Rican population |
| title_fullStr | High risk HPV testing for cervical cancer screening in a Puerto Rican population |
| title_full_unstemmed | High risk HPV testing for cervical cancer screening in a Puerto Rican population |
| title_short | High risk HPV testing for cervical cancer screening in a Puerto Rican population |
| title_sort | high risk hpv testing for cervical cancer screening in a puerto rican population |
| topic | Cervical cancer screening High Risk Human Papillomavirus Cytology Co-testing High grade squamous intraepithelial lesion (HSIL), Puerto Rico |
| url | http://www.sciencedirect.com/science/article/pii/S2352578923001054 |
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