Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Abstract Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 proforms, big-IGF2(87) and big-IGF2(104). Unprocessed and...

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Bibliographic Details
Main Authors: Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05239-6

Internet

https://doi.org/10.1038/s42003-023-05239-6

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