Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study
Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1: a double-blind, placebo-controlled, single a...
Main Authors: | Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-05-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.871492/full |
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