Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

ABSTRACTAnti-TNF therapy can induce and maintain a remission status during intestinal bowel disease. However, up to 30% of patients do not respond to this therapy by mechanisms that are unknown. Here, we show that the absence of MCJ, a natural inhibitor of the respiratory chain Complex I, induces gu...

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Bibliographic Details
Main Authors: Ainize Peña-Cearra, Janire Castelo, Jose Luis Lavín, Monika Gonzalez-Lopez, Miguel Angel Pascual-Itoiz, Miguel Fuertes, Virginia Gutiérrez de Juan, Laura Bárcena, Itziar Martín-Ruiz, Aize Pellón, Iratxe Seoane, Diego Barriales, Ainhoa Palacios, Asier Fullaondo, Iago Rodríguez-Lago, María L. Martinez-Chantar, Ana Mª Aransay, Hector Rodriguez, Juan Anguita, Leticia Abecia
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
IBD
microbiota
complex I
mitochondriopathy
FcγR signaling
anti-TNF therapy
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2266626

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2023.2266626

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