Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets
Ferulic acid (FA) is a phenolic compound that has antioxidant, hepatoprotective, anticarcinogenic, anti-inflammatory, antiallergic, antimicrobial, antiviral, and vasodilatory effects. This study was conducted to explore the effects of dietary FA supplementation on antioxidant capacity and lipid meta...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/12/3811 |
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| author | Youxia Wang Xiaoling Chen Zhiqing Huang Daiwen Chen Bing Yu Jie Yu Hong Chen Jun He Yuheng Luo Ping Zheng |
| author_facet | Youxia Wang Xiaoling Chen Zhiqing Huang Daiwen Chen Bing Yu Jie Yu Hong Chen Jun He Yuheng Luo Ping Zheng |
| author_sort | Youxia Wang |
| collection | DOAJ |
| description | Ferulic acid (FA) is a phenolic compound that has antioxidant, hepatoprotective, anticarcinogenic, anti-inflammatory, antiallergic, antimicrobial, antiviral, and vasodilatory effects. This study was conducted to explore the effects of dietary FA supplementation on antioxidant capacity and lipid metabolism in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05%, and 0.45% FA groups. The results showed that, in serum, CAT and T-SOD activities and content of HDL-C were increased, but the content of MDA and the activities of T-CHO and LDL-C were decreased, by FA supplementation. In liver, dietary FA supplementation increased CAT, T-SOD, and GSH-PX activities and upregulated the mRNA levels of <i>SOD1</i>, <i>SOD2</i>, <i>CAT</i>, <i>GST</i>, <i>GPX1</i>, <i>GR</i>, <i>Nrf2</i>, <i>HSL</i>, <i>CPT1b</i>, and <i>PPARα</i> but decreased the contents of MDA and TG. Furthermore, dietary FA supplementation increased the protein level of Nrf2, HO-1, and NQO-1. In <i>longissimus dorsi</i> muscle, dietary FA supplementation increased the activity of T-SOD and the mRNA abundance of <i>SOD1</i>, <i>SOD2</i>, <i>CAT</i>, <i>GST</i>, <i>GPX1</i>, <i>GR,</i> and <i>Nrf2</i> but decreased the contents of MDA and T-CHO. Additionally, dietary FA supplementation increased the protein expressions of Nrf2, HO-1, and NQO1. Together, our data suggest that FA could improve antioxidant capacity and lipid metabolism in weaned piglets. |
| first_indexed | 2024-03-10T14:08:00Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T14:08:00Z |
| publishDate | 2020-12-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a754242a15da45d8b7d5721b75bb95a02023-11-21T00:31:16ZengMDPI AGNutrients2072-66432020-12-011212381110.3390/nu12123811Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned PigletsYouxia Wang0Xiaoling Chen1Zhiqing Huang2Daiwen Chen3Bing Yu4Jie Yu5Hong Chen6Jun He7Yuheng Luo8Ping Zheng9Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Food Science, Sichuan Agricultural University, Yaan 625014, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, ChinaFerulic acid (FA) is a phenolic compound that has antioxidant, hepatoprotective, anticarcinogenic, anti-inflammatory, antiallergic, antimicrobial, antiviral, and vasodilatory effects. This study was conducted to explore the effects of dietary FA supplementation on antioxidant capacity and lipid metabolism in weaned piglets. Eighteen 21-day-old castrated male DLY (Duroc × Landrace × Yorkshire) weaned piglets were randomly divided into control, 0.05%, and 0.45% FA groups. The results showed that, in serum, CAT and T-SOD activities and content of HDL-C were increased, but the content of MDA and the activities of T-CHO and LDL-C were decreased, by FA supplementation. In liver, dietary FA supplementation increased CAT, T-SOD, and GSH-PX activities and upregulated the mRNA levels of <i>SOD1</i>, <i>SOD2</i>, <i>CAT</i>, <i>GST</i>, <i>GPX1</i>, <i>GR</i>, <i>Nrf2</i>, <i>HSL</i>, <i>CPT1b</i>, and <i>PPARα</i> but decreased the contents of MDA and TG. Furthermore, dietary FA supplementation increased the protein level of Nrf2, HO-1, and NQO-1. In <i>longissimus dorsi</i> muscle, dietary FA supplementation increased the activity of T-SOD and the mRNA abundance of <i>SOD1</i>, <i>SOD2</i>, <i>CAT</i>, <i>GST</i>, <i>GPX1</i>, <i>GR,</i> and <i>Nrf2</i> but decreased the contents of MDA and T-CHO. Additionally, dietary FA supplementation increased the protein expressions of Nrf2, HO-1, and NQO1. Together, our data suggest that FA could improve antioxidant capacity and lipid metabolism in weaned piglets.https://www.mdpi.com/2072-6643/12/12/3811weaned pigletsferulic acidantioxidant capacitylipid metabolism |
| spellingShingle | Youxia Wang Xiaoling Chen Zhiqing Huang Daiwen Chen Bing Yu Jie Yu Hong Chen Jun He Yuheng Luo Ping Zheng Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets Nutrients weaned piglets ferulic acid antioxidant capacity lipid metabolism |
| title | Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets |
| title_full | Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets |
| title_fullStr | Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets |
| title_full_unstemmed | Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets |
| title_short | Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets |
| title_sort | dietary ferulic acid supplementation improves antioxidant capacity and lipid metabolism in weaned piglets |
| topic | weaned piglets ferulic acid antioxidant capacity lipid metabolism |
| url | https://www.mdpi.com/2072-6643/12/12/3811 |
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