One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults
There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3535 |
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| author | Paulina Maria Przybycien-Gaweda Tih Shih Lee Wee Shiong Lim Mei Sian Chong Philip Yap Chin Yee Cheong Iris Rawtaer Tau Ming Liew Xinyi Gwee Qi Gao Keng Bee Yap Tze Pin Ng |
| author_facet | Paulina Maria Przybycien-Gaweda Tih Shih Lee Wee Shiong Lim Mei Sian Chong Philip Yap Chin Yee Cheong Iris Rawtaer Tau Ming Liew Xinyi Gwee Qi Gao Keng Bee Yap Tze Pin Ng |
| author_sort | Paulina Maria Przybycien-Gaweda |
| collection | DOAJ |
| description | There is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD ± 221] vs. 510 [SD ± 290] pmol/L, <i>p</i> = 0.026), higher homocysteine (14.6 [SD ± 4.2] vs. 12.9 [SD ± 4.3], <i>p</i> = 0.018) and lower one-carbon index (Z-scores: −0.444 [SD ± 0.819] vs. −0.001 [SD ± 0.990], <i>p</i> = 0.006). Adjusted for confounders, significant associations with incident NCD were found for lower vitamin B12 (per-SD OR = 2.10, 95%CI = 1.26–3.52), higher homocysteine (per-SD OR = 1.96, 95%CI = 1.18–3.24) and lower one-carbon index (per-SD OR = 1.67, 95%CI = 1.06–2.64). Folate was not significantly associated with progression to NCD. Notably, low B12 in the presence of high folate was significantly associated with incident NCD (adjusted OR = 3.81, 95%CI = 1.04–13.9). Low B12, high homocysteine, low B12 in the presence of high folate, and a one-carbon index of hypo-methylation were independently associated with progression to NCD among cognitively normal. |
| first_indexed | 2024-03-10T01:26:07Z |
| format | Article |
| id | doaj.art-a75464cc77b54f48b5f7ce48df3e4fee |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:26:07Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-a75464cc77b54f48b5f7ce48df3e4fee2023-11-23T13:52:05ZengMDPI AGNutrients2072-66432022-08-011417353510.3390/nu14173535One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older AdultsPaulina Maria Przybycien-Gaweda0Tih Shih Lee1Wee Shiong Lim2Mei Sian Chong3Philip Yap4Chin Yee Cheong5Iris Rawtaer6Tau Ming Liew7Xinyi Gwee8Qi Gao9Keng Bee Yap10Tze Pin Ng11Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeLaboratory of Neurobehavioural Genomics, Duke-NUS Medical School, Singapore 169857, SingaporeInstitute of Geriatrics and Active Aging, Tan Tock Seng Hospital, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308433, SingaporeGeriatric Education and Research Institute, Singapore 768024, SingaporeDepartment of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, SingaporeDepartment of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore 768828, SingaporeDepartment of Psychiatry, Sengkang General Hospital, Singapore 544886, SingaporeDepartment of Psychiatry, Singapore General Hospital, Singapore 169608, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeDepartment of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore 308433, SingaporeDepartment of Medicine, Ng Teng Fong General Hospital, Singapore 609606, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeThere is a lack of evidence supporting an association between folate and vitamin B12 exposure with cognitive outcomes. We examined serum folate and vitamin B12 and plasma homocysteine in 690 cognitively-normal adults (aged ≥ 55) from the Singapore Longitudinal Aging Study (SLAS-2) followed-up over 4.5 years on incident neurocognitive disorder (NCD): mild cognitive impairment (MCI) and dementia. At follow-up, 5.7% (39) of participants developed NCD (34 MCI and 5 dementia). Comparing with those who remained cognitively-normal, participants progressed to NCD had significantly lower mean baseline vitamin B12 (420 [SD ± 221] vs. 510 [SD ± 290] pmol/L, <i>p</i> = 0.026), higher homocysteine (14.6 [SD ± 4.2] vs. 12.9 [SD ± 4.3], <i>p</i> = 0.018) and lower one-carbon index (Z-scores: −0.444 [SD ± 0.819] vs. −0.001 [SD ± 0.990], <i>p</i> = 0.006). Adjusted for confounders, significant associations with incident NCD were found for lower vitamin B12 (per-SD OR = 2.10, 95%CI = 1.26–3.52), higher homocysteine (per-SD OR = 1.96, 95%CI = 1.18–3.24) and lower one-carbon index (per-SD OR = 1.67, 95%CI = 1.06–2.64). Folate was not significantly associated with progression to NCD. Notably, low B12 in the presence of high folate was significantly associated with incident NCD (adjusted OR = 3.81, 95%CI = 1.04–13.9). Low B12, high homocysteine, low B12 in the presence of high folate, and a one-carbon index of hypo-methylation were independently associated with progression to NCD among cognitively normal.https://www.mdpi.com/2072-6643/14/17/3535folateB12homocysteinemild cognitive impairmentdementia |
| spellingShingle | Paulina Maria Przybycien-Gaweda Tih Shih Lee Wee Shiong Lim Mei Sian Chong Philip Yap Chin Yee Cheong Iris Rawtaer Tau Ming Liew Xinyi Gwee Qi Gao Keng Bee Yap Tze Pin Ng One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults Nutrients folate B12 homocysteine mild cognitive impairment dementia |
| title | One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults |
| title_full | One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults |
| title_fullStr | One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults |
| title_full_unstemmed | One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults |
| title_short | One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults |
| title_sort | one carbon metabolism biomarkers and risks of incident neurocognitive disorder among cognitively normal older adults |
| topic | folate B12 homocysteine mild cognitive impairment dementia |
| url | https://www.mdpi.com/2072-6643/14/17/3535 |
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