Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population
Post-traumatic stress (PTSD) disorder is a mental health condition that can occur after experiencing or witnessing a traumatic event. The 27-F earthquake that struck Chile in 2010 was one such event that had a significant impact on the mental health of the population. A study was conducted to invest...
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PeerJ Inc.
2023-09-01
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| Online Access: | https://peerj.com/articles/15870.pdf |
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| author | Juan-Luis Castillo-Navarrete Benjamin Vicente Kristin Schmidt Esteban Moraga-Escobar Romina Rojas-Ponce Paola Lagos Ximena Macaya Alejandra Guzman-Castillo |
| author_facet | Juan-Luis Castillo-Navarrete Benjamin Vicente Kristin Schmidt Esteban Moraga-Escobar Romina Rojas-Ponce Paola Lagos Ximena Macaya Alejandra Guzman-Castillo |
| author_sort | Juan-Luis Castillo-Navarrete |
| collection | DOAJ |
| description | Post-traumatic stress (PTSD) disorder is a mental health condition that can occur after experiencing or witnessing a traumatic event. The 27-F earthquake that struck Chile in 2010 was one such event that had a significant impact on the mental health of the population. A study was conducted to investigate the prevalence of PTSD and its associated factors among survivors of this earthquake. The study was a longitudinal design, involving a sample of 913 patients aged 18 to 75 years who attended 10 Primary Care Centers in Concepción, Chile. The Composite International Diagnostic Interview (CIDI) was used to assess both depressive episodes (DE) and PTSD before and after the earthquake. The study also involved genotyping studies using saliva samples from the participants, specifically focusing on the Val66Met and 5-HTTLPR polymorphisms. Statistical analysis was performed to examine the association between different variables and the presence of PTSD. These variables included demographic factors, family history of psychiatric disorders, DE, childhood maltreatment experiences, and critical traumatic events related to the earthquake. The results showed that the incidence of post-earthquake PTSD was 11.06%. No significant differences were found between the groups of participants who developed post-earthquake PTSD regarding the Val66Met or 5-HTTLPR polymorphisms. However, a significant association was found between the concomitant diagnosis of DE and the development of post-earthquake PTSD. The presence of DE doubled the risk of developing post-earthquake PTSD. The number of traumatic events experienced also had a statistically significant association with an increased risk of developing post-earthquake PTSD. The study’s limitations include the potential interference of different DE subtypes, the complexity of quantifying the degree of earthquake exposure experienced by each individual, and events entailing social disruption, such as looting, that can profoundly influence distress. In conclusion, the study found that PTSD following the 27-F earthquake in Chile was associated with a concomitant diagnosis of DE and the number of traumatic events experienced. The study did not find a significant association between PTSD and the Val66Met or 5-HTTLPR polymorphisms. The researchers recommend that mental health professionals should prioritize the detection and treatment of concomitant depressive episodes and exposure to critical traumatic events in survivors of disasters. They also suggest that further research is needed to better understand the relationship between genetic factors and post-disaster PTSD. |
| first_indexed | 2024-03-09T06:22:04Z |
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| institution | Directory Open Access Journal |
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| spelling | doaj.art-a75558497a334edf895157e3d5e87b3a2023-12-03T11:35:31ZengPeerJ Inc.PeerJ2167-83592023-09-0111e1587010.7717/peerj.15870Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean populationJuan-Luis Castillo-Navarrete0Benjamin Vicente1Kristin Schmidt2Esteban Moraga-Escobar3Romina Rojas-Ponce4Paola Lagos5Ximena Macaya6Alejandra Guzman-Castillo7Programa Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePrograma Neurociencias, Psiquiatría y Salud Mental, NEPSAM, Universidad de Concepción, Concepción, ChilePost-traumatic stress (PTSD) disorder is a mental health condition that can occur after experiencing or witnessing a traumatic event. The 27-F earthquake that struck Chile in 2010 was one such event that had a significant impact on the mental health of the population. A study was conducted to investigate the prevalence of PTSD and its associated factors among survivors of this earthquake. The study was a longitudinal design, involving a sample of 913 patients aged 18 to 75 years who attended 10 Primary Care Centers in Concepción, Chile. The Composite International Diagnostic Interview (CIDI) was used to assess both depressive episodes (DE) and PTSD before and after the earthquake. The study also involved genotyping studies using saliva samples from the participants, specifically focusing on the Val66Met and 5-HTTLPR polymorphisms. Statistical analysis was performed to examine the association between different variables and the presence of PTSD. These variables included demographic factors, family history of psychiatric disorders, DE, childhood maltreatment experiences, and critical traumatic events related to the earthquake. The results showed that the incidence of post-earthquake PTSD was 11.06%. No significant differences were found between the groups of participants who developed post-earthquake PTSD regarding the Val66Met or 5-HTTLPR polymorphisms. However, a significant association was found between the concomitant diagnosis of DE and the development of post-earthquake PTSD. The presence of DE doubled the risk of developing post-earthquake PTSD. The number of traumatic events experienced also had a statistically significant association with an increased risk of developing post-earthquake PTSD. The study’s limitations include the potential interference of different DE subtypes, the complexity of quantifying the degree of earthquake exposure experienced by each individual, and events entailing social disruption, such as looting, that can profoundly influence distress. In conclusion, the study found that PTSD following the 27-F earthquake in Chile was associated with a concomitant diagnosis of DE and the number of traumatic events experienced. The study did not find a significant association between PTSD and the Val66Met or 5-HTTLPR polymorphisms. The researchers recommend that mental health professionals should prioritize the detection and treatment of concomitant depressive episodes and exposure to critical traumatic events in survivors of disasters. They also suggest that further research is needed to better understand the relationship between genetic factors and post-disaster PTSD.https://peerj.com/articles/15870.pdfPosttraumatic stress disorderBDNF Val66Met Polymorphism5-HTTLPRPolymorphismDepressive episodeChild MaltreatmentEarthquake |
| spellingShingle | Juan-Luis Castillo-Navarrete Benjamin Vicente Kristin Schmidt Esteban Moraga-Escobar Romina Rojas-Ponce Paola Lagos Ximena Macaya Alejandra Guzman-Castillo Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population PeerJ Posttraumatic stress disorder BDNF Val66Met Polymorphism 5-HTTLPRPolymorphism Depressive episode Child Maltreatment Earthquake |
| title | Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population |
| title_full | Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population |
| title_fullStr | Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population |
| title_full_unstemmed | Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population |
| title_short | Interaction of Val66Met BDNF and 5-HTTLPR polymorphisms with prevalence of post-earthquake 27-F PTSD in Chilean population |
| title_sort | interaction of val66met bdnf and 5 httlpr polymorphisms with prevalence of post earthquake 27 f ptsd in chilean population |
| topic | Posttraumatic stress disorder BDNF Val66Met Polymorphism 5-HTTLPRPolymorphism Depressive episode Child Maltreatment Earthquake |
| url | https://peerj.com/articles/15870.pdf |
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