Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study
Introduction: Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=526;epage=531;aulast=Karahan |
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| author | Nermin Karahan Sirin Baspinar Kemal Kursat Bozkurt Eylem Caloglu Ibrahim Metin Ciris Nilgun Kapucuoglu |
| author_facet | Nermin Karahan Sirin Baspinar Kemal Kursat Bozkurt Eylem Caloglu Ibrahim Metin Ciris Nilgun Kapucuoglu |
| author_sort | Nermin Karahan |
| collection | DOAJ |
| description | Introduction: Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix. Materials and Methods: In our study, we used immunohistochemical methods for the evaluation of COX-2, MMP-2 and MMP-9 expression in tissue samples of 30 primary and 10 recurrent skin BCC cases. Results: Immunohistochemical COX-2 expression was significantly higher in the infiltrating pattern of BCC compared with the nodular (P = 0.005) and superficial (P = 0.041) subtypes in the primary BCC group. There was not a significant difference between nodular and superficial BCCs for COX-2 expression. In addition, COX-2 expression was significantly higher in the recurrent BCC group than in the primary BCC group (P = 0.030). There was no statistically significant difference between the histological subtypes of primary BCCs and between primary and recurrent BCCs for MMP-2 and MMP-9 expressions. Conclusions: Our data confirm previous findings that COX-2 and MMP-9 expressions are increased in BCC. Our results revealed an elevated COX-2 expression in recurrent BCCs. We suggest that COX-2 inhibition might have beneficial effects in BCCs, especially for the tumors with a higher level of COX-2 expression or aggressive phenotype. |
| first_indexed | 2024-12-10T04:41:11Z |
| format | Article |
| id | doaj.art-a758a621cb7a42368633f5ae48887425 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-10T04:41:11Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-a758a621cb7a42368633f5ae488874252022-12-22T02:01:53ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292011-01-0154352653110.4103/0377-4929.85086Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot studyNermin KarahanSirin BaspinarKemal Kursat BozkurtEylem CalogluIbrahim Metin CirisNilgun KapucuogluIntroduction: Basal cell carcinoma (BCC) is the most frequent malignant skin tumor. BCC rarely metastasizes, but it is often locally aggressive. Cyclooxygenase-2 (COX-2) is critical for tumor formation, angiogenesis and metastasis. Matrix metalloproteinases (MMPs) are the members of the family of zinc (Zn)- and calcium-dependent endopeptidases that degrade the extracellular matrix. Materials and Methods: In our study, we used immunohistochemical methods for the evaluation of COX-2, MMP-2 and MMP-9 expression in tissue samples of 30 primary and 10 recurrent skin BCC cases. Results: Immunohistochemical COX-2 expression was significantly higher in the infiltrating pattern of BCC compared with the nodular (P = 0.005) and superficial (P = 0.041) subtypes in the primary BCC group. There was not a significant difference between nodular and superficial BCCs for COX-2 expression. In addition, COX-2 expression was significantly higher in the recurrent BCC group than in the primary BCC group (P = 0.030). There was no statistically significant difference between the histological subtypes of primary BCCs and between primary and recurrent BCCs for MMP-2 and MMP-9 expressions. Conclusions: Our data confirm previous findings that COX-2 and MMP-9 expressions are increased in BCC. Our results revealed an elevated COX-2 expression in recurrent BCCs. We suggest that COX-2 inhibition might have beneficial effects in BCCs, especially for the tumors with a higher level of COX-2 expression or aggressive phenotype.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=526;epage=531;aulast=KarahanBasal cell carcinomaCOX-2MMP-2MMP-9recurrence |
| spellingShingle | Nermin Karahan Sirin Baspinar Kemal Kursat Bozkurt Eylem Caloglu Ibrahim Metin Ciris Nilgun Kapucuoglu Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study Indian Journal of Pathology and Microbiology Basal cell carcinoma COX-2 MMP-2 MMP-9 recurrence |
| title | Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study |
| title_full | Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study |
| title_fullStr | Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study |
| title_full_unstemmed | Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study |
| title_short | Increased expression of COX-2 in recurrent basal cell carcinoma of the skin: A pilot study |
| title_sort | increased expression of cox 2 in recurrent basal cell carcinoma of the skin a pilot study |
| topic | Basal cell carcinoma COX-2 MMP-2 MMP-9 recurrence |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=3;spage=526;epage=531;aulast=Karahan |
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