Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases
ABSTRACT: Clostridioides (Clostridium) difficile is the main causative agent of antimicrobial-related diarrhea in humans and a major pathogen-associated enteric disorder in foals and adult horses. Moreover, studies have suggested that animals are a possible reservoir of toxigenic C. difficile strain...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2021-05-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000800452&tlng=en |
| _version_ | 1818955593852911616 |
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| author | Amanda Nádia Diniz Diogo Soares Gonçalves Cruz Carolina Pantuzza Ramos Carlos Augusto Oliveira Júnior Isabella Caixeta Winter Jorge Tibúrcio Barbosa de Lima Armando de Mattos Carvalho Francisco Carlos Faria Lobato Rodrigo Otávio Silveira Silva |
| author_facet | Amanda Nádia Diniz Diogo Soares Gonçalves Cruz Carolina Pantuzza Ramos Carlos Augusto Oliveira Júnior Isabella Caixeta Winter Jorge Tibúrcio Barbosa de Lima Armando de Mattos Carvalho Francisco Carlos Faria Lobato Rodrigo Otávio Silveira Silva |
| author_sort | Amanda Nádia Diniz |
| collection | DOAJ |
| description | ABSTRACT: Clostridioides (Clostridium) difficile is the main causative agent of antimicrobial-related diarrhea in humans and a major pathogen-associated enteric disorder in foals and adult horses. Moreover, studies have suggested that animals are a possible reservoir of toxigenic C. difficile strains for humans. Despite this known importance, the epidemiology of C. difficile infection (CDI) in equine is still largely unknown. Therefore, this study described six cases of equine CDI occurring in Minas Gerais, Brazil, including the characterization of the isolates. All but one equine included in this research developed CDI after antimicrobial therapy, three of which occurred during hospitalization. Coinfection with Salmonella Heidelberg and S. Infantis was detected in three cases, making the antimicrobial treatment challenging. All animals recovered after metronidazole administration. All C. difficile isolates were susceptible to metronidazole and vancomycin, while three were resistant to moxifloxacin and two were resistant to clindamycin. The isolates were classified as RT126 (n = 4), RT078 (n = 1), and RT014/020 (n = 1), all previously reported infecting humans and animals worldwide. |
| first_indexed | 2024-12-20T10:40:32Z |
| format | Article |
| id | doaj.art-a758ceeab98d467aa7fd4fb0fece4fe0 |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-20T10:40:32Z |
| publishDate | 2021-05-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-a758ceeab98d467aa7fd4fb0fece4fe02022-12-21T19:43:33ZengUniversidade Federal de Santa MariaCiência Rural1678-45962021-05-0151810.1590/0103-8478cr20200878Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six casesAmanda Nádia Dinizhttps://orcid.org/0000-0002-5287-5779Diogo Soares Gonçalves Cruzhttps://orcid.org/0000-0002-8577-6849Carolina Pantuzza Ramoshttps://orcid.org/0000-0003-2792-058XCarlos Augusto Oliveira Júniorhttps://orcid.org/0000-0002-9609-0746Isabella Caixeta Winterhttps://orcid.org/0000-0001-9002-5532Jorge Tibúrcio Barbosa de Limahttps://orcid.org/0000-0003-3866-9247Armando de Mattos Carvalhohttps://orcid.org/0000-0003-3007-1144Francisco Carlos Faria Lobatohttps://orcid.org/0000-0002-0656-1285Rodrigo Otávio Silveira Silvahttps://orcid.org/0000-0003-0074-2488ABSTRACT: Clostridioides (Clostridium) difficile is the main causative agent of antimicrobial-related diarrhea in humans and a major pathogen-associated enteric disorder in foals and adult horses. Moreover, studies have suggested that animals are a possible reservoir of toxigenic C. difficile strains for humans. Despite this known importance, the epidemiology of C. difficile infection (CDI) in equine is still largely unknown. Therefore, this study described six cases of equine CDI occurring in Minas Gerais, Brazil, including the characterization of the isolates. All but one equine included in this research developed CDI after antimicrobial therapy, three of which occurred during hospitalization. Coinfection with Salmonella Heidelberg and S. Infantis was detected in three cases, making the antimicrobial treatment challenging. All animals recovered after metronidazole administration. All C. difficile isolates were susceptible to metronidazole and vancomycin, while three were resistant to moxifloxacin and two were resistant to clindamycin. The isolates were classified as RT126 (n = 4), RT078 (n = 1), and RT014/020 (n = 1), all previously reported infecting humans and animals worldwide.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000800452&tlng=enfoalshorsesnosocomialzoonosiscolitis |
| spellingShingle | Amanda Nádia Diniz Diogo Soares Gonçalves Cruz Carolina Pantuzza Ramos Carlos Augusto Oliveira Júnior Isabella Caixeta Winter Jorge Tibúrcio Barbosa de Lima Armando de Mattos Carvalho Francisco Carlos Faria Lobato Rodrigo Otávio Silveira Silva Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases Ciência Rural foals horses nosocomial zoonosis colitis |
| title | Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases |
| title_full | Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases |
| title_fullStr | Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases |
| title_full_unstemmed | Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases |
| title_short | Clostridioides (Clostridium) difficile-associated diarrhea in equine in Minas Gerais, Brazil: clinical and microbiological characterization of six cases |
| title_sort | clostridioides clostridium difficile associated diarrhea in equine in minas gerais brazil clinical and microbiological characterization of six cases |
| topic | foals horses nosocomial zoonosis colitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000800452&tlng=en |
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