Uterine Leiomyomas: An ENIGMA
Introduction: Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue commonly encountered in women of reproductive age group. Leiomyomas need hormonal milieu for their growth and maintenance. Unopposed estrogenic stimulation manifests as leiomyo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Journal of Mid-Life Health |
| Subjects: | |
| Online Access: | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2016;volume=7;issue=1;spage=22;epage=27;aulast=Geethamala |
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| author | Kempula Geethamala Venkataramappa Srinivasa Murthy Bangalore Ramalingiah Vani Sudha Rao |
| author_facet | Kempula Geethamala Venkataramappa Srinivasa Murthy Bangalore Ramalingiah Vani Sudha Rao |
| author_sort | Kempula Geethamala |
| collection | DOAJ |
| description | Introduction: Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue commonly encountered in women of reproductive age group. Leiomyomas need hormonal milieu for their growth and maintenance. Unopposed estrogenic stimulation manifests as leiomyomas undergoing secondary changes, endometrial proliferation or hyperplasia, and other associated pathological findings.
Objective: To study and analyze various histopathological changes within uterine leiomyomas in hysterectomy specimens. And also, to analyze the associated endometrial and adnexal structures pathology.
Materials and Methods: A 4 years retrospective study from June 2010 to June 2014 conducted in the Department of Pathology and Obstetrics and Gynecology, ESIC Medical College and PGIMSR, wherein 820 hysterectomy specimens clinically diagnosed as uterine leiomyomas were subjected to histopathological examination and relevant clinical data were analyzed.
Results: Leiomyomas occurred mostly in women aged 31-50 years (90.23%). Menorrhagia (49.36%) and pain abdomen (30.6%) were the chief clinical manifestations. Endometrial patterns commonly seen were proliferative and hyperplastic endometrium together accounting for 73.4% and dual pathology with adenomyosis was 29.1%. Four cases of tubercular etiology and a single case of granulosa cell tumor of ovary was noted.
Conclusion: Though hysterectomy is a routine procedure in the management of uterine leiomyomas, occasional cases of tumor or infective pathology may be missed. Therefore, histopathology is mandatory and conscientious quest must be done for confirmed diagnosis and ensuring optimal management. |
| first_indexed | 2024-12-19T08:21:19Z |
| format | Article |
| id | doaj.art-a759046a041b420a87e9cf9ee29133a2 |
| institution | Directory Open Access Journal |
| issn | 0976-7800 0976-7819 |
| language | English |
| last_indexed | 2024-12-19T08:21:19Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Mid-Life Health |
| spelling | doaj.art-a759046a041b420a87e9cf9ee29133a22022-12-21T20:29:24ZengWolters Kluwer Medknow PublicationsJournal of Mid-Life Health0976-78000976-78192016-01-0171222710.4103/0976-7800.179170Uterine Leiomyomas: An ENIGMAKempula GeethamalaVenkataramappa Srinivasa MurthyBangalore Ramalingiah VaniSudha RaoIntroduction: Leiomyomas are benign tumors composed of smooth muscle cells and varying amounts of fibrous connective tissue commonly encountered in women of reproductive age group. Leiomyomas need hormonal milieu for their growth and maintenance. Unopposed estrogenic stimulation manifests as leiomyomas undergoing secondary changes, endometrial proliferation or hyperplasia, and other associated pathological findings. Objective: To study and analyze various histopathological changes within uterine leiomyomas in hysterectomy specimens. And also, to analyze the associated endometrial and adnexal structures pathology. Materials and Methods: A 4 years retrospective study from June 2010 to June 2014 conducted in the Department of Pathology and Obstetrics and Gynecology, ESIC Medical College and PGIMSR, wherein 820 hysterectomy specimens clinically diagnosed as uterine leiomyomas were subjected to histopathological examination and relevant clinical data were analyzed. Results: Leiomyomas occurred mostly in women aged 31-50 years (90.23%). Menorrhagia (49.36%) and pain abdomen (30.6%) were the chief clinical manifestations. Endometrial patterns commonly seen were proliferative and hyperplastic endometrium together accounting for 73.4% and dual pathology with adenomyosis was 29.1%. Four cases of tubercular etiology and a single case of granulosa cell tumor of ovary was noted. Conclusion: Though hysterectomy is a routine procedure in the management of uterine leiomyomas, occasional cases of tumor or infective pathology may be missed. Therefore, histopathology is mandatory and conscientious quest must be done for confirmed diagnosis and ensuring optimal management.http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2016;volume=7;issue=1;spage=22;epage=27;aulast=GeethamalaEndometrial changes, hysterectomy, leiomyomas |
| spellingShingle | Kempula Geethamala Venkataramappa Srinivasa Murthy Bangalore Ramalingiah Vani Sudha Rao Uterine Leiomyomas: An ENIGMA Journal of Mid-Life Health Endometrial changes, hysterectomy, leiomyomas |
| title | Uterine Leiomyomas: An ENIGMA |
| title_full | Uterine Leiomyomas: An ENIGMA |
| title_fullStr | Uterine Leiomyomas: An ENIGMA |
| title_full_unstemmed | Uterine Leiomyomas: An ENIGMA |
| title_short | Uterine Leiomyomas: An ENIGMA |
| title_sort | uterine leiomyomas an enigma |
| topic | Endometrial changes, hysterectomy, leiomyomas |
| url | http://www.jmidlifehealth.org/article.asp?issn=0976-7800;year=2016;volume=7;issue=1;spage=22;epage=27;aulast=Geethamala |
| work_keys_str_mv | AT kempulageethamala uterineleiomyomasanenigma AT venkataramappasrinivasamurthy uterineleiomyomasanenigma AT bangaloreramalingiahvani uterineleiomyomasanenigma AT sudharao uterineleiomyomasanenigma |