Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

Homocysteine (Hcy) as an independent risk factor contributes to the occurrence and development of human cardiovascular diseases (CVD). Induction of oxidative stress and apoptosis was commonly accepted as the major mechanism in Hcy-induced cardiotoxicity. Astaxanthin (ATX) as one of the most powerful...

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Bibliographic Details
Main Authors: Cun-dong Fan, Jing-yi Sun, Xiao-ting Fu, Ya-jun Hou, Yuan Li, Ming-feng Yang, Xiao-yan Fu, Bao-liang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Physiology
Subjects:
homocysteine
astaxanthin
cardiovascular diseases
mitochondrial dysfunction
oxidative damage
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.01041/full

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