Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila.
Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. In this study, we showed that juvenile hormone (JH) is involved in regul...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-04-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5909909?pdf=render |
| _version_ | 1818565368390615040 |
|---|---|
| author | Binbin Wu Lingling Ma Enyan Zhang Juan Du Suning Liu Jeffrey Price Sheng Li Zhangwu Zhao |
| author_facet | Binbin Wu Lingling Ma Enyan Zhang Juan Du Suning Liu Jeffrey Price Sheng Li Zhangwu Zhao |
| author_sort | Binbin Wu |
| collection | DOAJ |
| description | Sexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. In this study, we showed that juvenile hormone (JH) is involved in regulation of sexually dimorphic sleep in Drosophila, in which gain of JH function enlarges differences of the dimorphic sleep phenotype with higher sleep in males and lower sleep in females, while loss of JH function blurs these differences and results in feminization of male sleep and masculinization of female sleep. Further studies indicate that germ cell-expressed (GCE), one of the JH receptors, mediates the response in the JH pathway because the sexually dimorphic sleep phenotypes cannot be rescued by JH hormone in a gce deletion mutant. The JH-GCE regulated sleep dimorphism is generated through the sex differentiation-related genes -fruitless (fru) and doublesex (dsx) in males and sex-lethal (sxl), transformer (tra) and doublesex (dsx) in females. These are the "switch" genes that separately control the sleep pattern in males and females. Moreover, analysis of sleep deprivation and circadian behaviors showed that the sexually dimorphic sleep induced by JH signals is a change of sleep drive and independent of the circadian clock. Furthermore, we found that JH seems to also play an unanticipated role in antagonism of an aging-induced sleep decrease in male flies. Taken together, these results indicate that the JH signal pathway is critical for maintenance of sexually dimorphic sleep by regulating sex-relevant genes. |
| first_indexed | 2024-12-14T01:40:20Z |
| format | Article |
| id | doaj.art-a75d486b79444c6ea701ee93f28c7e4e |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-14T01:40:20Z |
| publishDate | 2018-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-a75d486b79444c6ea701ee93f28c7e4e2022-12-21T23:21:46ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042018-04-01144e100731810.1371/journal.pgen.1007318Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila.Binbin WuLingling MaEnyan ZhangJuan DuSuning LiuJeffrey PriceSheng LiZhangwu ZhaoSexually dimorphic phenotypes are a universal phenomenon in animals. In the model animal fruit fly Drosophila, males and females exhibit long- and short-sleep phenotypes, respectively. However, the mechanism is still a mystery. In this study, we showed that juvenile hormone (JH) is involved in regulation of sexually dimorphic sleep in Drosophila, in which gain of JH function enlarges differences of the dimorphic sleep phenotype with higher sleep in males and lower sleep in females, while loss of JH function blurs these differences and results in feminization of male sleep and masculinization of female sleep. Further studies indicate that germ cell-expressed (GCE), one of the JH receptors, mediates the response in the JH pathway because the sexually dimorphic sleep phenotypes cannot be rescued by JH hormone in a gce deletion mutant. The JH-GCE regulated sleep dimorphism is generated through the sex differentiation-related genes -fruitless (fru) and doublesex (dsx) in males and sex-lethal (sxl), transformer (tra) and doublesex (dsx) in females. These are the "switch" genes that separately control the sleep pattern in males and females. Moreover, analysis of sleep deprivation and circadian behaviors showed that the sexually dimorphic sleep induced by JH signals is a change of sleep drive and independent of the circadian clock. Furthermore, we found that JH seems to also play an unanticipated role in antagonism of an aging-induced sleep decrease in male flies. Taken together, these results indicate that the JH signal pathway is critical for maintenance of sexually dimorphic sleep by regulating sex-relevant genes.http://europepmc.org/articles/PMC5909909?pdf=render |
| spellingShingle | Binbin Wu Lingling Ma Enyan Zhang Juan Du Suning Liu Jeffrey Price Sheng Li Zhangwu Zhao Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. PLoS Genetics |
| title | Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. |
| title_full | Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. |
| title_fullStr | Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. |
| title_full_unstemmed | Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. |
| title_short | Sexual dimorphism of sleep regulated by juvenile hormone signaling in Drosophila. |
| title_sort | sexual dimorphism of sleep regulated by juvenile hormone signaling in drosophila |
| url | http://europepmc.org/articles/PMC5909909?pdf=render |
| work_keys_str_mv | AT binbinwu sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT linglingma sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT enyanzhang sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT juandu sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT suningliu sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT jeffreyprice sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT shengli sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila AT zhangwuzhao sexualdimorphismofsleepregulatedbyjuvenilehormonesignalingindrosophila |