Lumbar spine intervertebral disc gene delivery of BMPs induces anterior spine fusion in lewis rats

Abstract Minimally invasive techniques and biological autograft alternatives such as the bone morphogenetic proteins (BMPs) can reduce morbidity associated with spinal fusions. This study was a proof-of-concept for gene-therapy-mediated anterior spine fusion that could be adapted to percutaneous tec...

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Bibliographic Details
Main Authors: Matthew E. Cunningham, Natalie H. Kelly, Bernard A. Rawlins, Oheneba Boachie-Adjei, Marjolein C. H. van der Meulen, Chisa Hidaka
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-21208-1