An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function. While the development of potent IP6K inhibitors is gaining momentum, a pharmacological tool to distinguish the mammali...

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Bibliographic Details
Main Authors: Tim Aguirre, Gillian L Dornan, Sarah Hostachy, Martin Neuenschwander, Carola Seyffarth, Volker Haucke, Anja Schütz, Jens Peter von Kries, Dorothea Fiedler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-10-01
Series:eLife
Subjects:
kinase
inositol phosphate
allosteric inhibitor
analog-sensitive
Online Access:https://elifesciences.org/articles/88982

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