Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia

Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia

Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly remain an underrepresented population in pre-clinical cancer studies and clinical trials. The immune system plays a critical role in the effectiveness of many anti-cancer therapies in young hosts via tumor-sp...

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Bibliographic Details
Main Authors: Lelinh Duong, Hannah G. Radley-Crabb, Joanne K. Gardner, Federica Tomay, Danielle E. Dye, Miranda D. Grounds, Fiona J. Pixley, Delia J. Nelson, Connie Jackaman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Genetics
Subjects:
macrophage
aging
cancer
immunotherapy
T cells
cachexia
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00526/full

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