Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron
Traditional concepts of life sciences consider oxidative stress as a fundamental process of aging and various diseases including cancer, whereas traditional medicine recommends dietary intake of iron to support physiological functions of the organism. However, due to its strong pro-oxidative capacit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/3/191 |
| _version_ | 1797719244959383552 |
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| author | Morana Jaganjac Suzana Borovic Sunjic Neven Zarkovic |
| author_facet | Morana Jaganjac Suzana Borovic Sunjic Neven Zarkovic |
| author_sort | Morana Jaganjac |
| collection | DOAJ |
| description | Traditional concepts of life sciences consider oxidative stress as a fundamental process of aging and various diseases including cancer, whereas traditional medicine recommends dietary intake of iron to support physiological functions of the organism. However, due to its strong pro-oxidative capacity, if not controlled well, iron can trigger harmful oxidative stress manifested eventually by toxic chain reactions of lipid peroxidation. Such effects of iron are considered to be major disadvantages of uncontrolled iron usage, although ferroptosis seems to be an important defense mechanism attenuating cancer development. Therefore, a variety of iron-containing nanoparticles were developed for experimental radio-, chemo-, and photodynamic as well as magnetic dynamic nanosystems that alter redox homeostasis in cancer cells. Moreover, studies carried over recent decades have revealed that even the end products of lipid peroxidation, represented by 4-hydroxynonenal (4-HNE), could have desirable effects even acting as kinds of selective anticancer substances produced by non-malignant cells for defense again invading cancer. Therefore, advanced nanotechnologies should be developed for using iron to trigger targeted lipid peroxidation as an anticancer option of integrative biomedicine. |
| first_indexed | 2024-03-12T09:01:59Z |
| format | Article |
| id | doaj.art-a75f418475404fafb31c4f1861f2a650 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T09:01:59Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a75f418475404fafb31c4f1861f2a6502023-09-02T15:36:54ZengMDPI AGAntioxidants2076-39212020-02-019319110.3390/antiox9030191antiox9030191Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing IronMorana Jaganjac0Suzana Borovic Sunjic1Neven Zarkovic2Qatar Analytics & BioResearch Laboratory, Anti Doping Laboratory Qatar, Doha, QatarRudjer Boskovic Institute, Laboratory for Oxidative Stress, Division of Molecular Medicine, Bijenicka 54, 10000 Zagreb, CroatiaRudjer Boskovic Institute, Laboratory for Oxidative Stress, Division of Molecular Medicine, Bijenicka 54, 10000 Zagreb, CroatiaTraditional concepts of life sciences consider oxidative stress as a fundamental process of aging and various diseases including cancer, whereas traditional medicine recommends dietary intake of iron to support physiological functions of the organism. However, due to its strong pro-oxidative capacity, if not controlled well, iron can trigger harmful oxidative stress manifested eventually by toxic chain reactions of lipid peroxidation. Such effects of iron are considered to be major disadvantages of uncontrolled iron usage, although ferroptosis seems to be an important defense mechanism attenuating cancer development. Therefore, a variety of iron-containing nanoparticles were developed for experimental radio-, chemo-, and photodynamic as well as magnetic dynamic nanosystems that alter redox homeostasis in cancer cells. Moreover, studies carried over recent decades have revealed that even the end products of lipid peroxidation, represented by 4-hydroxynonenal (4-HNE), could have desirable effects even acting as kinds of selective anticancer substances produced by non-malignant cells for defense again invading cancer. Therefore, advanced nanotechnologies should be developed for using iron to trigger targeted lipid peroxidation as an anticancer option of integrative biomedicine.https://www.mdpi.com/2076-3921/9/3/191ironnanomedicinereactive oxygen speciesferroptosis4-hydroxynonenal |
| spellingShingle | Morana Jaganjac Suzana Borovic Sunjic Neven Zarkovic Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron Antioxidants iron nanomedicine reactive oxygen species ferroptosis 4-hydroxynonenal |
| title | Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron |
| title_full | Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron |
| title_fullStr | Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron |
| title_full_unstemmed | Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron |
| title_short | Utilizing Iron for Targeted Lipid Peroxidation as Anticancer Option of Integrative Biomedicine: A Short Review of Nanosystems Containing Iron |
| title_sort | utilizing iron for targeted lipid peroxidation as anticancer option of integrative biomedicine a short review of nanosystems containing iron |
| topic | iron nanomedicine reactive oxygen species ferroptosis 4-hydroxynonenal |
| url | https://www.mdpi.com/2076-3921/9/3/191 |
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