Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period
Environmental enrichment (EE) has been shown to promote neural plasticity. Its capacity to induce functional repair in models which exhibit profound sensory deficits due to aberrant axonal guidance has not been well-characterized. Ten-m3 knockout (KO) mice exhibit a highly-stereotyped miswiring of i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00022/full |
| _version_ | 1819081293312294912 |
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| author | James Blok Dylan A. Black Justin Petersen Atomu Sawatari Catherine A. Leamey |
| author_facet | James Blok Dylan A. Black Justin Petersen Atomu Sawatari Catherine A. Leamey |
| author_sort | James Blok |
| collection | DOAJ |
| description | Environmental enrichment (EE) has been shown to promote neural plasticity. Its capacity to induce functional repair in models which exhibit profound sensory deficits due to aberrant axonal guidance has not been well-characterized. Ten-m3 knockout (KO) mice exhibit a highly-stereotyped miswiring of ipsilateral retinogeniculate axons and associated profound deficits in binocularly-mediated visual behavior. We determined whether, and when, EE can drive functional recovery by analyzing Ten-m3 KO and wildtype (WT) mice that were enriched for 6 weeks from adulthood, weaning or birth in comparison to standard-housed controls. EE initiated from birth, but not later, rescued the response of Ten-m3 KOs to the “looming” stimulus (expanding disc in dorsal visual field), suggesting improved visual function. EE can thus induce recovery of visual behavior, but only during an early developmentally-restricted time-window. |
| first_indexed | 2024-12-21T19:58:28Z |
| format | Article |
| id | doaj.art-a75fb6115753456899cf5e299ef00fdf |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-21T19:58:28Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-a75fb6115753456899cf5e299ef00fdf2022-12-21T18:52:02ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532020-02-011410.3389/fnbeh.2020.00022450015Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical PeriodJames BlokDylan A. BlackJustin PetersenAtomu SawatariCatherine A. LeameyEnvironmental enrichment (EE) has been shown to promote neural plasticity. Its capacity to induce functional repair in models which exhibit profound sensory deficits due to aberrant axonal guidance has not been well-characterized. Ten-m3 knockout (KO) mice exhibit a highly-stereotyped miswiring of ipsilateral retinogeniculate axons and associated profound deficits in binocularly-mediated visual behavior. We determined whether, and when, EE can drive functional recovery by analyzing Ten-m3 KO and wildtype (WT) mice that were enriched for 6 weeks from adulthood, weaning or birth in comparison to standard-housed controls. EE initiated from birth, but not later, rescued the response of Ten-m3 KOs to the “looming” stimulus (expanding disc in dorsal visual field), suggesting improved visual function. EE can thus induce recovery of visual behavior, but only during an early developmentally-restricted time-window.https://www.frontiersin.org/article/10.3389/fnbeh.2020.00022/fullvisual developmentplasticityenvironmental enrichmentipsilateralsubcorticalten-m/Teneurin/Odz |
| spellingShingle | James Blok Dylan A. Black Justin Petersen Atomu Sawatari Catherine A. Leamey Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period Frontiers in Behavioral Neuroscience visual development plasticity environmental enrichment ipsilateral subcortical ten-m/Teneurin/Odz |
| title | Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period |
| title_full | Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period |
| title_fullStr | Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period |
| title_full_unstemmed | Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period |
| title_short | Environmental Enrichment Rescues Visually-Mediated Behavior in Ten-m3 Knockout Mice During an Early Critical Period |
| title_sort | environmental enrichment rescues visually mediated behavior in ten m3 knockout mice during an early critical period |
| topic | visual development plasticity environmental enrichment ipsilateral subcortical ten-m/Teneurin/Odz |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2020.00022/full |
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