ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis

ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis

Oxidative disruption of dopaminergic neurons is regarded as a crucial pathogenesis in Parkinson's disease (PD), eventually causing neurodegenerative progression. (-)-Clausenamide (Clau) is an alkaloid isolated from plant Clausena lansium (Lour.), which is well-known as a scavenger of lipid pero...

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Bibliographic Details
Main Authors: Kun Li, Meng Wang, Zi-Han Huang, Min Wang, Wan-Yang Sun, Hiroshi Kurihara, Rui-Ting Huang, Rong Wang, Feng Huang, Lei Liang, Yi-Fang Li, Wen-Jun Duan, Rong-Rong He
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Pharmacological Research
Subjects:
Parkinson's disease
(-)-Clausenamide
5-Lipoxygenase
Lipid peroxides
Ferroptosis
Oxidative damage
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823001354

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http://www.sciencedirect.com/science/article/pii/S1043661823001354

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