Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications

Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications

The integrin αIIbβ3 is the most abundant integrin on platelets. Upon platelet activation, the integrin changes its conformation (inside-out signalling) and outside-in signalling takes place leading to platelet spreading, platelet aggregation and thrombus formation. Bloodsucking parasites such as mos...

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Bibliographic Details
Main Authors:	Danique L. van den Kerkhof, Paola E.J. van der Meijden, Tilman M. Hackeng, Ingrid Dijkgraaf
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	International Journal of Molecular Sciences
Subjects:	platelets integrin αIIbβ3 antagonists hematophagous parasites
Online Access:	https://www.mdpi.com/1422-0067/22/7/3366

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