Hesperidin: A Therapeutic Agent For Obesity
Haijun Xiong,1 Jin Wang,1 Qian Ran,1 Guanhua Lou,1 Chengyi Peng,1 Qingxia Gan,1 Ju Hu,1 Jilin Sun,2 Renchuan Yao,3 Qinwan Huang1,4 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China; 2Sichuan Fuzheng Pharmaceutical Co. Ltd,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-11-01
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| Series: | Drug Design, Development and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/hesperidin-a-therapeutic-agent-for-obesity-peer-reviewed-article-DDDT |
| _version_ | 1818997596281110528 |
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| author | Xiong H Wang J Ran Q Lou G Peng C Gan Q Hu J Sun J Yao R Huang Q |
| author_facet | Xiong H Wang J Ran Q Lou G Peng C Gan Q Hu J Sun J Yao R Huang Q |
| author_sort | Xiong H |
| collection | DOAJ |
| description | Haijun Xiong,1 Jin Wang,1 Qian Ran,1 Guanhua Lou,1 Chengyi Peng,1 Qingxia Gan,1 Ju Hu,1 Jilin Sun,2 Renchuan Yao,3 Qinwan Huang1,4 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China; 2Sichuan Fuzheng Pharmaceutical Co. Ltd, Sichuan, People’s Republic of China; 3Sichuan Fermentation Traditional Chinese Medicine Engineering Research Center, Chengdu, People’s Republic of China; 4State Key Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of ChinaCorrespondence: Qinwan HuangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu 611137, People’s Republic of ChinaTel +86 13982199974Fax +61800231Email hqwan2163@163.comAbstract: Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.Keywords: citrus flavonoids, lipid metabolism, glucose metabolism, anti-oxidation, anti-inflammatory |
| first_indexed | 2024-12-20T21:48:09Z |
| format | Article |
| id | doaj.art-a7623fad662742d8a3932d8d17ff77b8 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-20T21:48:09Z |
| publishDate | 2019-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-a7623fad662742d8a3932d8d17ff77b82022-12-21T19:25:38ZengDove Medical PressDrug Design, Development and Therapy1177-88812019-11-01Volume 133855386649712Hesperidin: A Therapeutic Agent For ObesityXiong HWang JRan QLou GPeng CGan QHu JSun JYao RHuang QHaijun Xiong,1 Jin Wang,1 Qian Ran,1 Guanhua Lou,1 Chengyi Peng,1 Qingxia Gan,1 Ju Hu,1 Jilin Sun,2 Renchuan Yao,3 Qinwan Huang1,4 1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China; 2Sichuan Fuzheng Pharmaceutical Co. Ltd, Sichuan, People’s Republic of China; 3Sichuan Fermentation Traditional Chinese Medicine Engineering Research Center, Chengdu, People’s Republic of China; 4State Key Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of ChinaCorrespondence: Qinwan HuangCollege of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu 611137, People’s Republic of ChinaTel +86 13982199974Fax +61800231Email hqwan2163@163.comAbstract: Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against obesity diseases. Our review discusses mechanisms of hesperidin in the treatment of obesity. Hesperidin regulates lipid metabolism and glucose metabolism by mediating AMPK and PPAR signaling pathways, directly regulates antioxidant index and anti-apoptosis, and indirectly mediates NF-κB signaling pathway to regulate inflammation to play a role in the treatment of obesity. In addition, hesperidin-enriched dietary supplements can significantly improve symptoms such as postprandial hyperglycemia and hyperlipidemia. Further clinical trials are also required for confirming lipid-lowering efficacy of this natural flavonoid and evaluating its safety profile.Keywords: citrus flavonoids, lipid metabolism, glucose metabolism, anti-oxidation, anti-inflammatoryhttps://www.dovepress.com/hesperidin-a-therapeutic-agent-for-obesity-peer-reviewed-article-DDDTcitrus flavonoidslipid metabolismglucose metabolismanti-oxidationanti-inflammatory |
| spellingShingle | Xiong H Wang J Ran Q Lou G Peng C Gan Q Hu J Sun J Yao R Huang Q Hesperidin: A Therapeutic Agent For Obesity Drug Design, Development and Therapy citrus flavonoids lipid metabolism glucose metabolism anti-oxidation anti-inflammatory |
| title | Hesperidin: A Therapeutic Agent For Obesity |
| title_full | Hesperidin: A Therapeutic Agent For Obesity |
| title_fullStr | Hesperidin: A Therapeutic Agent For Obesity |
| title_full_unstemmed | Hesperidin: A Therapeutic Agent For Obesity |
| title_short | Hesperidin: A Therapeutic Agent For Obesity |
| title_sort | hesperidin a therapeutic agent for obesity |
| topic | citrus flavonoids lipid metabolism glucose metabolism anti-oxidation anti-inflammatory |
| url | https://www.dovepress.com/hesperidin-a-therapeutic-agent-for-obesity-peer-reviewed-article-DDDT |
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