The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial
Background and aims: Given the prevalence of urolithiasis and the popularity of black radish extract for the treatment of this problem, the present study was designed to investigate its effect in alkalizing urine in stone-forming patients referred to Imam Ali clinic in Shahrekord (Iran). Methods: In...
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| Format: | Article |
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Shahrekord University of Medical Sciences
2022-11-01
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| Series: | Future Natural Products |
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| Online Access: | http://futurenatprod.skums.ac.ir/article_252379_10602b911b150e32a05bd083a6130cd9.pdf |
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| author | Majid Shirani Zahra Vasei Morteza Sedehi Sareh Mohammadi Elham Bijad Solomon Habtemariam Mohammad Rahimi–Madiseh Zahra Lorigooini |
| author_facet | Majid Shirani Zahra Vasei Morteza Sedehi Sareh Mohammadi Elham Bijad Solomon Habtemariam Mohammad Rahimi–Madiseh Zahra Lorigooini |
| author_sort | Majid Shirani |
| collection | DOAJ |
| description | Background and aims: Given the prevalence of urolithiasis and the popularity of black radish extract for the treatment of this problem, the present study was designed to investigate its effect in alkalizing urine in stone-forming patients referred to Imam Ali clinic in Shahrekord (Iran). Methods: In this clinical trial, the urine pH was measured along with the 24-hour urine assessment for urine volume and urine citrate, oxalate, calcium, uric acid, and creatinine levels of 20 patients before and after the intervention. Results: The results showed a significant increase (P < 0.001) in mean urine pH after the administration of Raphanus sativus syrup for 14 days. The mean 24-hour urine volume and citrate level increased significantly (P < 0.05). In addition, the mean uric acid and oxalate levels decreased significantly (P < 0.05). Mean changes in 24-hour urine creatinine and calcium levels were not statistically significant after intervention (P > 0.05). Conclusion: Raphanus sativus extract treatment can increase urine pH, urine citrate level, and urine volume and decreases uric acid and oxalate levels. Therefore, the plant may be used for the treatment and prevention of uric acid and cystine stones. |
| first_indexed | 2024-04-10T19:04:47Z |
| format | Article |
| id | doaj.art-a76254a75ddb4fdfb679f753f5f7ac0e |
| institution | Directory Open Access Journal |
| issn | 2783-4662 |
| language | English |
| last_indexed | 2024-04-10T19:04:47Z |
| publishDate | 2022-11-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Future Natural Products |
| spelling | doaj.art-a76254a75ddb4fdfb679f753f5f7ac0e2023-01-31T06:15:38ZengShahrekord University of Medical SciencesFuture Natural Products2783-46622022-11-0182303410.34172/fnp.2022.07252379The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trialMajid Shirani0Zahra Vasei1Morteza Sedehi2Sareh Mohammadi3Elham Bijad4Solomon Habtemariam5Mohammad Rahimi–Madiseh6Zahra Lorigooini7Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranPharmacognosy Research Laboratories and Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UKMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranBackground and aims: Given the prevalence of urolithiasis and the popularity of black radish extract for the treatment of this problem, the present study was designed to investigate its effect in alkalizing urine in stone-forming patients referred to Imam Ali clinic in Shahrekord (Iran). Methods: In this clinical trial, the urine pH was measured along with the 24-hour urine assessment for urine volume and urine citrate, oxalate, calcium, uric acid, and creatinine levels of 20 patients before and after the intervention. Results: The results showed a significant increase (P < 0.001) in mean urine pH after the administration of Raphanus sativus syrup for 14 days. The mean 24-hour urine volume and citrate level increased significantly (P < 0.05). In addition, the mean uric acid and oxalate levels decreased significantly (P < 0.05). Mean changes in 24-hour urine creatinine and calcium levels were not statistically significant after intervention (P > 0.05). Conclusion: Raphanus sativus extract treatment can increase urine pH, urine citrate level, and urine volume and decreases uric acid and oxalate levels. Therefore, the plant may be used for the treatment and prevention of uric acid and cystine stones.http://futurenatprod.skums.ac.ir/article_252379_10602b911b150e32a05bd083a6130cd9.pdfblack radishurine phkidney stones |
| spellingShingle | Majid Shirani Zahra Vasei Morteza Sedehi Sareh Mohammadi Elham Bijad Solomon Habtemariam Mohammad Rahimi–Madiseh Zahra Lorigooini The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial Future Natural Products black radish urine ph kidney stones |
| title | The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial |
| title_full | The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial |
| title_fullStr | The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial |
| title_full_unstemmed | The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial |
| title_short | The effect of aqueous extract of black radish root on urine pH in stone-forming patients: A single blind clinical trial |
| title_sort | effect of aqueous extract of black radish root on urine ph in stone forming patients a single blind clinical trial |
| topic | black radish urine ph kidney stones |
| url | http://futurenatprod.skums.ac.ir/article_252379_10602b911b150e32a05bd083a6130cd9.pdf |
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