Widespread perturbation of ETS factor binding sites in cancer
Few cancer drivers in non-coding regions have been identified so far. Here, the authors develop a transcription factor-aware burden test to predict non-coding variants and analyze the impact on transcription factor binding - especially ETS factors - as well as their impact on transcriptional activit...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36535-8 |
| _version_ | 1797864103454179328 |
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| author | Sebastian Carrasco Pro Heather Hook David Bray Daniel Berenzy Devlin Moyer Meimei Yin Adam Thomas Labadorf Ryan Tewhey Trevor Siggers Juan Ignacio Fuxman Bass |
| author_facet | Sebastian Carrasco Pro Heather Hook David Bray Daniel Berenzy Devlin Moyer Meimei Yin Adam Thomas Labadorf Ryan Tewhey Trevor Siggers Juan Ignacio Fuxman Bass |
| author_sort | Sebastian Carrasco Pro |
| collection | DOAJ |
| description | Few cancer drivers in non-coding regions have been identified so far. Here, the authors develop a transcription factor-aware burden test to predict non-coding variants and analyze the impact on transcription factor binding - especially ETS factors - as well as their impact on transcriptional activity. |
| first_indexed | 2024-04-09T22:47:14Z |
| format | Article |
| id | doaj.art-a763016e6eb44adfaaaf42af058e49e9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:14Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a763016e6eb44adfaaaf42af058e49e92023-03-22T11:49:26ZengNature PortfolioNature Communications2041-17232023-02-0114111510.1038/s41467-023-36535-8Widespread perturbation of ETS factor binding sites in cancerSebastian Carrasco Pro0Heather Hook1David Bray2Daniel Berenzy3Devlin Moyer4Meimei Yin5Adam Thomas Labadorf6Ryan Tewhey7Trevor Siggers8Juan Ignacio Fuxman Bass9Bioinformatics Program, Boston UniversityDepartment of Biology, Boston UniversityBioinformatics Program, Boston UniversityThe Jackson LaboratoryBioinformatics Program, Boston UniversityDepartment of Biology, Boston UniversityBioinformatics Hub, Boston UniversityThe Jackson LaboratoryBioinformatics Program, Boston UniversityBioinformatics Program, Boston UniversityFew cancer drivers in non-coding regions have been identified so far. Here, the authors develop a transcription factor-aware burden test to predict non-coding variants and analyze the impact on transcription factor binding - especially ETS factors - as well as their impact on transcriptional activity.https://doi.org/10.1038/s41467-023-36535-8 |
| spellingShingle | Sebastian Carrasco Pro Heather Hook David Bray Daniel Berenzy Devlin Moyer Meimei Yin Adam Thomas Labadorf Ryan Tewhey Trevor Siggers Juan Ignacio Fuxman Bass Widespread perturbation of ETS factor binding sites in cancer Nature Communications |
| title | Widespread perturbation of ETS factor binding sites in cancer |
| title_full | Widespread perturbation of ETS factor binding sites in cancer |
| title_fullStr | Widespread perturbation of ETS factor binding sites in cancer |
| title_full_unstemmed | Widespread perturbation of ETS factor binding sites in cancer |
| title_short | Widespread perturbation of ETS factor binding sites in cancer |
| title_sort | widespread perturbation of ets factor binding sites in cancer |
| url | https://doi.org/10.1038/s41467-023-36535-8 |
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