Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis
The third ventricle width (3VW) is an easily calculated measure of brain atrophy. The aim of this study was to evaluate the relation of 3VW to cognitive impairment with adjustment for demographic and clinical confounders, including depression, anxiety, and fatigue, as well as to disability in patien...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/10/2841 |
| _version_ | 1797498897302552576 |
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| author | Wojciech Guenter Ewa Betscher Robert Bonek |
| author_facet | Wojciech Guenter Ewa Betscher Robert Bonek |
| author_sort | Wojciech Guenter |
| collection | DOAJ |
| description | The third ventricle width (3VW) is an easily calculated measure of brain atrophy. The aim of this study was to evaluate the relation of 3VW to cognitive impairment with adjustment for demographic and clinical confounders, including depression, anxiety, and fatigue, as well as to disability in patients with multiple sclerosis (MS). Symbol Digit Modalities Test, California Verbal Learning Test, Brief Visuospatial Memory Test-Revised, Expanded Disability Status Scale (EDSS), Hospital Anxiety and Depression Scale, and Modified Fatigue Impact Scale (MFIS) were analysed in 93 patients with MS. Neuropsychological performance was compared to that of 150 healthy controls. Axial images from 3D FLAIR were used to measure 3VW. In total, 25% of MS patients were impaired in at least two neuropsychological tests. Cognitive impairment and EDSS were associated with 3VW. Age and 3VW were the strongest predictors of cognitive impairment. The multiple regression model including age, 3VW, education, EDSS, and MFIS explained 63% of the variance of neuropsychological tests results, whereas 3VW, age and duration of the disease were significant predictors of EDSS. This study confirms the predictive value of 3VW for neurological status of patients with MS, especially for cognitive impairment after adjustment for demographic and clinical confounders. |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:39:49Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-a76340766aac4025918152576598da132023-11-23T11:35:40ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-011110284110.3390/jcm11102841Predictive Value of the Third Ventricle Width for Neurological Status in Multiple SclerosisWojciech Guenter0Ewa Betscher1Robert Bonek2Department of Clinical Neuropsychology, Nicolaus Copernicus University, 87-100 Toruń, Poland, and Collegium Medicum, 85-094 Bydgoszcz, PolandDivision of Neurology and Clinical Neuroimmunology, Regional Specialized Hospital in Grudziądz, 86-300 Grudziądz, PolandDivision of Neurology and Clinical Neuroimmunology, Regional Specialized Hospital in Grudziądz, 86-300 Grudziądz, PolandThe third ventricle width (3VW) is an easily calculated measure of brain atrophy. The aim of this study was to evaluate the relation of 3VW to cognitive impairment with adjustment for demographic and clinical confounders, including depression, anxiety, and fatigue, as well as to disability in patients with multiple sclerosis (MS). Symbol Digit Modalities Test, California Verbal Learning Test, Brief Visuospatial Memory Test-Revised, Expanded Disability Status Scale (EDSS), Hospital Anxiety and Depression Scale, and Modified Fatigue Impact Scale (MFIS) were analysed in 93 patients with MS. Neuropsychological performance was compared to that of 150 healthy controls. Axial images from 3D FLAIR were used to measure 3VW. In total, 25% of MS patients were impaired in at least two neuropsychological tests. Cognitive impairment and EDSS were associated with 3VW. Age and 3VW were the strongest predictors of cognitive impairment. The multiple regression model including age, 3VW, education, EDSS, and MFIS explained 63% of the variance of neuropsychological tests results, whereas 3VW, age and duration of the disease were significant predictors of EDSS. This study confirms the predictive value of 3VW for neurological status of patients with MS, especially for cognitive impairment after adjustment for demographic and clinical confounders.https://www.mdpi.com/2077-0383/11/10/2841multiple sclerosiscognitive impairmentEDSSmagnetic resonance imagingthe width of the third ventricle |
| spellingShingle | Wojciech Guenter Ewa Betscher Robert Bonek Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis Journal of Clinical Medicine multiple sclerosis cognitive impairment EDSS magnetic resonance imaging the width of the third ventricle |
| title | Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis |
| title_full | Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis |
| title_fullStr | Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis |
| title_full_unstemmed | Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis |
| title_short | Predictive Value of the Third Ventricle Width for Neurological Status in Multiple Sclerosis |
| title_sort | predictive value of the third ventricle width for neurological status in multiple sclerosis |
| topic | multiple sclerosis cognitive impairment EDSS magnetic resonance imaging the width of the third ventricle |
| url | https://www.mdpi.com/2077-0383/11/10/2841 |
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