Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic
Fanconi anaemia (FA) is an autosomal recessive inherited disease that renders patients susceptible to congenital anomalies, bone marrow failures, leukaemia, and solid malignancies. FA is caused by the loss of function of at least one gene in the FA/BRCA biological pathway, which is involved in DNA r...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-09-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/526698 |
| _version_ | 1798027880856289280 |
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| author | Shobina Sivanganam Mohd Faizal Abdullah Shaifulizan Abdul Rahman |
| author_facet | Shobina Sivanganam Mohd Faizal Abdullah Shaifulizan Abdul Rahman |
| author_sort | Shobina Sivanganam |
| collection | DOAJ |
| description | Fanconi anaemia (FA) is an autosomal recessive inherited disease that renders patients susceptible to congenital anomalies, bone marrow failures, leukaemia, and solid malignancies. FA is caused by the loss of function of at least one gene in the FA/BRCA biological pathway, which is involved in DNA repair. Patients with FA have an increased risk of developing head and neck cancer, particularly oral squamous cell carcinoma (SCC). Due to susceptibility of head and neck cancer at a very young age, relatively poor survival rate, low tolerance to oncologic interventions, and complexity of treatments, strict follow-up is mandatory to detect any changes or recurrence of SCC in the head and neck region in FA patients. Surgery is the mainstay of treatment, but adjuvant therapy should be instituted when needed. This short report describes a rare case of lower lip SCC in FA and its management. It also highlights the impact of the COVID-19 pandemic on healthcare practices. |
| first_indexed | 2024-04-11T18:58:47Z |
| format | Article |
| id | doaj.art-a7646009c3f6473fa0ff370229c5c48f |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-11T18:58:47Z |
| publishDate | 2022-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-a7646009c3f6473fa0ff370229c5c48f2022-12-22T04:08:06ZengKarger PublishersCase Reports in Oncology1662-65752022-09-0115384885310.1159/000526698526698Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 PandemicShobina Sivanganam0Mohd Faizal Abdullah1https://orcid.org/0000-0002-6587-1902Shaifulizan Abdul Rahman2Oral and Maxillofacial Surgery Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MalaysiaOral and Maxillofacial Surgery Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MalaysiaOral and Maxillofacial Surgery Unit, School of Dental Sciences, Health Campus, Universiti Sains Malaysia, Kota Bharu, MalaysiaFanconi anaemia (FA) is an autosomal recessive inherited disease that renders patients susceptible to congenital anomalies, bone marrow failures, leukaemia, and solid malignancies. FA is caused by the loss of function of at least one gene in the FA/BRCA biological pathway, which is involved in DNA repair. Patients with FA have an increased risk of developing head and neck cancer, particularly oral squamous cell carcinoma (SCC). Due to susceptibility of head and neck cancer at a very young age, relatively poor survival rate, low tolerance to oncologic interventions, and complexity of treatments, strict follow-up is mandatory to detect any changes or recurrence of SCC in the head and neck region in FA patients. Surgery is the mainstay of treatment, but adjuvant therapy should be instituted when needed. This short report describes a rare case of lower lip SCC in FA and its management. It also highlights the impact of the COVID-19 pandemic on healthcare practices.https://www.karger.com/Article/FullText/526698fanconi anaemiahead and neck canceroral squamous cell carcinomacovid-19 |
| spellingShingle | Shobina Sivanganam Mohd Faizal Abdullah Shaifulizan Abdul Rahman Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic Case Reports in Oncology fanconi anaemia head and neck cancer oral squamous cell carcinoma covid-19 |
| title | Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic |
| title_full | Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic |
| title_fullStr | Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic |
| title_full_unstemmed | Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic |
| title_short | Extensive Lower Lip Squamous Cell Carcinoma in a Fanconi Anaemia Patient and Treatment Delays during COVID-19 Pandemic |
| title_sort | extensive lower lip squamous cell carcinoma in a fanconi anaemia patient and treatment delays during covid 19 pandemic |
| topic | fanconi anaemia head and neck cancer oral squamous cell carcinoma covid-19 |
| url | https://www.karger.com/Article/FullText/526698 |
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