Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase

Reversal of High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Metformin Combined with PGG, an Inducer of Glycine N-Methyltransferase

Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidities and mortality, and no effective drug treatment currently exists. We aimed to develop a novel treatment strategy to induce the expression of glycine N-methyltransferase (GNMT), which is an important enzyme regulati...

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Bibliographic Details
Main Authors: Ming-Hui Yang, Wei-You Li, Ching-Fen Wu, Yi-Ching Lee, Allan Yi-Nan Chen, Yu-Chang Tyan, Yi-Ming Arthur Chen
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
glycine N-methyltransferase
metformin
1,2,3,4,6-pentagalloyl glucose
nonalcoholic fatty liver disease
mitochondria
Online Access:https://www.mdpi.com/1422-0067/23/17/10072

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https://www.mdpi.com/1422-0067/23/17/10072

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