Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity

Opioids are highly effective analgesics that have a serious potential for adverse drug reactions and for development of addiction and tolerance. Since the use of opioids has escalated in recent years, it is increasingly important to understand biological mechanisms that can increase the probability...

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Bibliographic Details
Main Authors: Junzhi Yang, Bianca G. Reilly, Thomas P. Davis, Patrick T. Ronaldson
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
Online Access:http://www.mdpi.com/1999-4923/10/4/192