Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma
Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors. However, the specific biological function of FDX1 in glioma is currently unclear. To explore the potential...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.939776/full |
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| author | Hanwen Lu Hanwen Lu Liwei Zhou Liwei Zhou Bingchang Zhang Bingchang Zhang Yuanyuan Xie Yuanyuan Xie Huiyin Yang Huiyin Yang Zhanxiang Wang Zhanxiang Wang Zhanxiang Wang |
| author_facet | Hanwen Lu Hanwen Lu Liwei Zhou Liwei Zhou Bingchang Zhang Bingchang Zhang Yuanyuan Xie Yuanyuan Xie Huiyin Yang Huiyin Yang Zhanxiang Wang Zhanxiang Wang Zhanxiang Wang |
| author_sort | Hanwen Lu |
| collection | DOAJ |
| description | Recent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors. However, the specific biological function of FDX1 in glioma is currently unclear. To explore the potential function of FDX1, this study explored the correlation between the expression of FDX1 in cancers and survival prognosis by analyzing the public databases of GEPIA and Cbioportal. Immune infiltration was analyzed by the TIMER2.0 database in tumors. The possible biological processes and functions of FDX1-related in glioma were annotated through gene enrichment. Relationship between Cuproptosis and autophagy was explored through gene co-expression studies. Summary and conclusions of this study: (1) FDX1 is highly expressed in gliomas and associated with poor prognosis in low-grade gliomas (LGG). (2) Gene annotation indicates that FDX1 is mainly involved in the tumor protein lipoylation and cell death. (3) FDX1 expression is positively correlated with the infiltration of immune cells. (4) LIPT2 and NNAT, two other genes involved in lipoylation, may be unidentified marker gene for Cuproptosis. And the Cuproptosis genes related to FDX1 were positively correlated with the expression of autophagy marker genes Atg5, Atg12, and BECN-1. This evidence suggests that there may be some interaction between FDX1 mediated Cuproptosis and autophagy. In summary, FDX1 may serve as a potential immunotherapy target and prognostic marker for Glioma. |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T00:31:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-a766e6fc084a42d1bce97fb0333e7be62023-07-10T13:23:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.939776939776Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in gliomaHanwen Lu0Hanwen Lu1Liwei Zhou2Liwei Zhou3Bingchang Zhang4Bingchang Zhang5Yuanyuan Xie6Yuanyuan Xie7Huiyin Yang8Huiyin Yang9Zhanxiang Wang10Zhanxiang Wang11Zhanxiang Wang12Department of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, Institute of Neurosurgery, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, Institute of Neurosurgery, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, Xiamen Key Laboratory of Brain Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neuroscience, Institute of Neurosurgery, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaRecent studies have found that the protein encoded by the FDX1 gene is involved in mediating Cuproptosis as a regulator of protein lipoylation and related to immune response process of tumors. However, the specific biological function of FDX1 in glioma is currently unclear. To explore the potential function of FDX1, this study explored the correlation between the expression of FDX1 in cancers and survival prognosis by analyzing the public databases of GEPIA and Cbioportal. Immune infiltration was analyzed by the TIMER2.0 database in tumors. The possible biological processes and functions of FDX1-related in glioma were annotated through gene enrichment. Relationship between Cuproptosis and autophagy was explored through gene co-expression studies. Summary and conclusions of this study: (1) FDX1 is highly expressed in gliomas and associated with poor prognosis in low-grade gliomas (LGG). (2) Gene annotation indicates that FDX1 is mainly involved in the tumor protein lipoylation and cell death. (3) FDX1 expression is positively correlated with the infiltration of immune cells. (4) LIPT2 and NNAT, two other genes involved in lipoylation, may be unidentified marker gene for Cuproptosis. And the Cuproptosis genes related to FDX1 were positively correlated with the expression of autophagy marker genes Atg5, Atg12, and BECN-1. This evidence suggests that there may be some interaction between FDX1 mediated Cuproptosis and autophagy. In summary, FDX1 may serve as a potential immunotherapy target and prognostic marker for Glioma.https://www.frontiersin.org/articles/10.3389/fmed.2022.939776/fullCuproptosisgliomaprognostic biomarkerimmune infiltrationlipoylation |
| spellingShingle | Hanwen Lu Hanwen Lu Liwei Zhou Liwei Zhou Bingchang Zhang Bingchang Zhang Yuanyuan Xie Yuanyuan Xie Huiyin Yang Huiyin Yang Zhanxiang Wang Zhanxiang Wang Zhanxiang Wang Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma Frontiers in Medicine Cuproptosis glioma prognostic biomarker immune infiltration lipoylation |
| title | Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma |
| title_full | Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma |
| title_fullStr | Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma |
| title_full_unstemmed | Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma |
| title_short | Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma |
| title_sort | cuproptosis key gene fdx1 is a prognostic biomarker and associated with immune infiltration in glioma |
| topic | Cuproptosis glioma prognostic biomarker immune infiltration lipoylation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.939776/full |
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