Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit
Background and Objectives: Oxidative stress due to free radicals formation plays an important role in noise-induced hearing loss (NIHL). Many hypotheses have been proposed regarding the biochemical prevention of this complication. This study was performed with the purpose of determining the preventi...
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| Format: | Article |
| Language: | fas |
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Qom University of Medical Sciences
2013-04-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
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| Online Access: | http://journal.muq.ac.ir/article-1-517-en.html |
| _version_ | 1818559438162755584 |
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| author | Masoud Motalebi Kashani Mitra Hannani Mohammad Sabahi-Bidgoli Alireza Dehdashti Hamid-Reza Saberi |
| author_facet | Masoud Motalebi Kashani Mitra Hannani Mohammad Sabahi-Bidgoli Alireza Dehdashti Hamid-Reza Saberi |
| author_sort | Masoud Motalebi Kashani |
| collection | DOAJ |
| description | Background and Objectives: Oxidative stress due to free radicals formation plays an important role in noise-induced hearing loss (NIHL). Many hypotheses have been proposed regarding the biochemical prevention of this complication. This study was performed with the purpose of determining the preventive effect of N-acetylcysteine (NAC) administration, as an antioxidant agent, on NIHL in Rabbit.
Methods: In an experimental study, 24 adult white male rabbits were divided into four groups, including: 1) control, 2) noise exposure (100dB octave band noise centered at 4000Hz for 40h), 3) noise exposure plus NAC administration (325mg/kg, daily ip injection), and 4) no exposure and NAC administration. Audiometric test of rabbits was assessed by auditory brainstem response (ABR) technique in three stages. The Kruskal-Wallis and Mann-Whitney tests were used to compare the groups, and a p<0.05 was considered significant.
Results: The mean ABR threshold shift for the noise exposure plus NAC administration group, 1 hour after exposure at 1, 2, 4 and 8kHz frequencies were, respectively, 16.66±1.63, 21.66±1.75, 33.5±2.34, and 39.33±2.25dB. These values were significantly less than the same values in the noise exposure group.
Conclusion: The results of this study showed that NAC can provide a proper protective effect against hearing loss resulting from noise exposure. |
| first_indexed | 2024-12-14T00:25:30Z |
| format | Article |
| id | doaj.art-a76748b5571a42988be37711e6cbae6a |
| institution | Directory Open Access Journal |
| issn | 1735-7799 2008-1375 |
| language | fas |
| last_indexed | 2024-12-14T00:25:30Z |
| publishDate | 2013-04-01 |
| publisher | Qom University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum |
| spelling | doaj.art-a76748b5571a42988be37711e6cbae6a2022-12-21T23:25:04ZfasQom University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum1735-77992008-13752013-04-01713441Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in RabbitMasoud Motalebi Kashani0Mitra Hannani1Mohammad Sabahi-Bidgoli2Alireza Dehdashti3Hamid-Reza Saberi4 Kashan University of Medical Sciences Kashan University of Medical Sciences Kashan University of Medical Sciences Kashan University of Medical Sciences Kashan University of Medical Sciences Background and Objectives: Oxidative stress due to free radicals formation plays an important role in noise-induced hearing loss (NIHL). Many hypotheses have been proposed regarding the biochemical prevention of this complication. This study was performed with the purpose of determining the preventive effect of N-acetylcysteine (NAC) administration, as an antioxidant agent, on NIHL in Rabbit. Methods: In an experimental study, 24 adult white male rabbits were divided into four groups, including: 1) control, 2) noise exposure (100dB octave band noise centered at 4000Hz for 40h), 3) noise exposure plus NAC administration (325mg/kg, daily ip injection), and 4) no exposure and NAC administration. Audiometric test of rabbits was assessed by auditory brainstem response (ABR) technique in three stages. The Kruskal-Wallis and Mann-Whitney tests were used to compare the groups, and a p<0.05 was considered significant. Results: The mean ABR threshold shift for the noise exposure plus NAC administration group, 1 hour after exposure at 1, 2, 4 and 8kHz frequencies were, respectively, 16.66±1.63, 21.66±1.75, 33.5±2.34, and 39.33±2.25dB. These values were significantly less than the same values in the noise exposure group. Conclusion: The results of this study showed that NAC can provide a proper protective effect against hearing loss resulting from noise exposure.http://journal.muq.ac.ir/article-1-517-en.htmlhearing lossnoise inducedevoked potentialsauditorybrain stemacetylcysteine |
| spellingShingle | Masoud Motalebi Kashani Mitra Hannani Mohammad Sabahi-Bidgoli Alireza Dehdashti Hamid-Reza Saberi Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum hearing loss noise induced evoked potentials auditory brain stem acetylcysteine |
| title | Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit |
| title_full | Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit |
| title_fullStr | Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit |
| title_full_unstemmed | Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit |
| title_short | Protective Effect of N-acetylcysteine (NAC) Administration on Prevention of Noise-Induced Hearing Loss (NIHL) in Rabbit |
| title_sort | protective effect of n acetylcysteine nac administration on prevention of noise induced hearing loss nihl in rabbit |
| topic | hearing loss noise induced evoked potentials auditory brain stem acetylcysteine |
| url | http://journal.muq.ac.ir/article-1-517-en.html |
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