Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis
A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavit...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753924000010 |
| _version_ | 1797253924117282816 |
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| author | Mário Pinto João Rodrigues Marta Silva Dionísio Maia António Miguel |
| author_facet | Mário Pinto João Rodrigues Marta Silva Dionísio Maia António Miguel |
| author_sort | Mário Pinto |
| collection | DOAJ |
| description | A 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma resolution were achieved, with no toxicity or side effects, and the clinical benefits were sustained at six months of follow-up. |
| first_indexed | 2024-03-08T12:52:37Z |
| format | Article |
| id | doaj.art-a769fa3b8b3c4d0dbeecf3b09c5004e3 |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-04-24T21:41:47Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-a769fa3b8b3c4d0dbeecf3b09c5004e32024-03-21T05:36:41ZengElsevierMedical Mycology Case Reports2211-75392024-03-0143100627Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosisMário Pinto0João Rodrigues1Marta Silva2Dionísio Maia3António Miguel4Corresponding author.; Interventional Pulmonology Unit, Pulmonology Department, University Hospital Center of Central Lisbon, Rua de Santa Marta 50, Lisbon, 1169-024, PortugalInterventional Pulmonology Unit, Pulmonology Department, University Hospital Center of Central Lisbon, Rua de Santa Marta 50, Lisbon, 1169-024, PortugalInterventional Pulmonology Unit, Pulmonology Department, University Hospital Center of Central Lisbon, Rua de Santa Marta 50, Lisbon, 1169-024, PortugalInterventional Pulmonology Unit, Pulmonology Department, University Hospital Center of Central Lisbon, Rua de Santa Marta 50, Lisbon, 1169-024, PortugalInterventional Pulmonology Unit, Pulmonology Department, University Hospital Center of Central Lisbon, Rua de Santa Marta 50, Lisbon, 1169-024, PortugalA 37-year-old man presented with chronic cavitary pulmonary aspergillosis and hemoptysis refractory to systemic antifungal therapy with voriconazole and bronchial artery embolization. Surgical excision was unfeasible due to the patient's refusal of blood transfusions. Ten sessions of intracavitary instillation of amphotericin B via flexible bronchoscopy were then performed. Hemoptysis cessation and aspergilloma resolution were achieved, with no toxicity or side effects, and the clinical benefits were sustained at six months of follow-up.http://www.sciencedirect.com/science/article/pii/S2211753924000010Pulmonary aspergillosisAspergillomaHemoptysisFlexible bronchoscopyAmphotericin B |
| spellingShingle | Mário Pinto João Rodrigues Marta Silva Dionísio Maia António Miguel Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis Medical Mycology Case Reports Pulmonary aspergillosis Aspergilloma Hemoptysis Flexible bronchoscopy Amphotericin B |
| title | Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis |
| title_full | Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis |
| title_fullStr | Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis |
| title_full_unstemmed | Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis |
| title_short | Endobronchial amphotericin B to treat hemoptysis in an inoperable patient with aspergillosis |
| title_sort | endobronchial amphotericin b to treat hemoptysis in an inoperable patient with aspergillosis |
| topic | Pulmonary aspergillosis Aspergilloma Hemoptysis Flexible bronchoscopy Amphotericin B |
| url | http://www.sciencedirect.com/science/article/pii/S2211753924000010 |
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