Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice

Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice

Background: The neuroinflammation of the central nervous system (CNS) is a prevalent syndrome of brain dysfunction secondary to severe sepsis and is regulated by microglia. Triggering the receptor expressed on myeloid cells 2 (TREM2) is known to have protective functions that modulate the microglial...

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Bibliographic Details
Main Authors: Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong Miao
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Brain Sciences
Subjects:
sepsis
microglia polarization
neuroinflammation
TREM2
Online Access:https://www.mdpi.com/2076-3425/13/1/126

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