Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection
Abstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleuk...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100659&lng=en&tlng=en |
| _version_ | 1817978842834272256 |
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| author | Marcos Braz Joyce Moura Oliveira Jamile Leão Rêgo Edgar Marcelino de Carvalho Silvane Maria Braga Santos Léa Cristina Castellucci |
| author_facet | Marcos Braz Joyce Moura Oliveira Jamile Leão Rêgo Edgar Marcelino de Carvalho Silvane Maria Braga Santos Léa Cristina Castellucci |
| author_sort | Marcos Braz |
| collection | DOAJ |
| description | Abstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes. RESULTS No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001). CONCLUSIONS Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections. |
| first_indexed | 2024-04-13T22:35:32Z |
| format | Article |
| id | doaj.art-a76d041fe5ec4af29b93e73e5b5c1786 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:35:32Z |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-a76d041fe5ec4af29b93e73e5b5c17862022-12-22T02:26:47ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984952010.1590/0037-8682-0481-2018S0037-86822019000100659Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infectionMarcos BrazJoyce Moura OliveiraJamile Leão RêgoEdgar Marcelino de CarvalhoSilvane Maria Braga SantosLéa Cristina CastellucciAbstract INTRODUCTION Human T-cell lymphotropic virus type 1 (HTLV-1)-associated inflammatory diseases are not well understood; however, their clinical manifestations may be influenced by the host genetic background. METHODS We genotyped 298 individuals with HTLV-1 and 380 controls for interleukin-10 (IL10) gene variants-rs3024496, rs1800871, rs1800896-and used logistic regression analysis to determine their association with clinical phenotypes. RESULTS No association with HTLV-1 infection was observed. However, allele A of rs1800896 (1082bp upstream) was associated with protection against neurological impairment, specifically overactive bladder (OR=0.447, 95% CI 0.28-0.70, p=0.001). CONCLUSIONS Our data suggests that IL10 regulation ameliorates neurological damage in HTLV-1 infections.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100659&lng=en&tlng=enHTLV-1SNP rs1800896 (-1082bp A/G)Overactive bladder |
| spellingShingle | Marcos Braz Joyce Moura Oliveira Jamile Leão Rêgo Edgar Marcelino de Carvalho Silvane Maria Braga Santos Léa Cristina Castellucci Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection Revista da Sociedade Brasileira de Medicina Tropical HTLV-1 SNP rs1800896 (-1082bp A/G) Overactive bladder |
| title | Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection |
| title_full | Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection |
| title_fullStr | Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection |
| title_full_unstemmed | Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection |
| title_short | Polymorphism in the interleukin-10 gene is associated with overactive bladder phenotype associated with HTLV-1 infection |
| title_sort | polymorphism in the interleukin 10 gene is associated with overactive bladder phenotype associated with htlv 1 infection |
| topic | HTLV-1 SNP rs1800896 (-1082bp A/G) Overactive bladder |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100659&lng=en&tlng=en |
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