Iron and glutathione at the crossroad of redox metabolism in neurons
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here,...
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| Format: | Article |
| Language: | English |
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BMC
2006-01-01
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| Series: | Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017 |
| _version_ | 1811264351252774912 |
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| author | PAULA ARACENA PABLA AGUIRRE PABLO MUÑOZ MARCO T NÚÑEZ |
| author_facet | PAULA ARACENA PABLA AGUIRRE PABLO MUÑOZ MARCO T NÚÑEZ |
| author_sort | PAULA ARACENA |
| collection | DOAJ |
| description | Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death. |
| first_indexed | 2024-04-12T20:01:33Z |
| format | Article |
| id | doaj.art-a76d43e198904aaba11ecd3bf15ae6cd |
| institution | Directory Open Access Journal |
| issn | 0716-9760 0717-6287 |
| language | English |
| last_indexed | 2024-04-12T20:01:33Z |
| publishDate | 2006-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Research |
| spelling | doaj.art-a76d43e198904aaba11ecd3bf15ae6cd2022-12-22T03:18:31ZengBMCBiological Research0716-97600717-62872006-01-01391157165Iron and glutathione at the crossroad of redox metabolism in neuronsPAULA ARACENAPABLA AGUIRREPABLO MUÑOZMARCO T NÚÑEZNeurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017neuronsiron metabolismiron accumulationoxidative stressglutathione metabolismneurodegeneration |
| spellingShingle | PAULA ARACENA PABLA AGUIRRE PABLO MUÑOZ MARCO T NÚÑEZ Iron and glutathione at the crossroad of redox metabolism in neurons Biological Research neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration |
| title | Iron and glutathione at the crossroad of redox metabolism in neurons |
| title_full | Iron and glutathione at the crossroad of redox metabolism in neurons |
| title_fullStr | Iron and glutathione at the crossroad of redox metabolism in neurons |
| title_full_unstemmed | Iron and glutathione at the crossroad of redox metabolism in neurons |
| title_short | Iron and glutathione at the crossroad of redox metabolism in neurons |
| title_sort | iron and glutathione at the crossroad of redox metabolism in neurons |
| topic | neurons iron metabolism iron accumulation oxidative stress glutathione metabolism neurodegeneration |
| url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017 |
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