Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics
Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/10/1568 |
| _version_ | 1797714177238761472 |
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| author | Quirino Lai Alessandro Vitale Tommaso M. Manzia Francesco G. Foschi Giovanni B. Levi Sandri Martina Gambato Fabio Melandro Francesco P. Russo Luca Miele Luca Viganò Patrizia Burra Edoardo G. Giannini on behalf of the Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group |
| author_facet | Quirino Lai Alessandro Vitale Tommaso M. Manzia Francesco G. Foschi Giovanni B. Levi Sandri Martina Gambato Fabio Melandro Francesco P. Russo Luca Miele Luca Viganò Patrizia Burra Edoardo G. Giannini on behalf of the Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group |
| author_sort | Quirino Lai |
| collection | DOAJ |
| description | Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC. |
| first_indexed | 2024-03-12T07:48:04Z |
| format | Article |
| id | doaj.art-a76d4efa8cd74d68aef60ff73ca1160a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T07:48:04Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a76d4efa8cd74d68aef60ff73ca1160a2023-09-02T20:51:31ZengMDPI AGCancers2072-66942019-10-011110156810.3390/cancers11101568cancers11101568Platelets and Hepatocellular Cancer: Bridging the Bench to the ClinicsQuirino Lai0Alessandro Vitale1Tommaso M. Manzia2Francesco G. Foschi3Giovanni B. Levi Sandri4Martina Gambato5Fabio Melandro6Francesco P. Russo7Luca Miele8Luca Viganò9Patrizia Burra10Edoardo G. Giannini11on behalf of the Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group12Department of General Surgery and Organ Transplantation, Umberto I Hospital, Sapienza University, 00161 Rome, ItalyDepartment of Surgery, Oncology, and Gastroenterology, University of Padua, 35122 Padua, ItalyDepartment of Transplant Surgery, Polyclinic Tor Vergata Foundation, Tor Vergata University, 00133 Rome, ItalyDepartment of Internal Medicine, Ospedale per gli Infermi di Faenza, 48018 Faenza, ItalyDepartment of Surgery, Sant’Eugenio Hospital, 00144 Rome, ItalyDepartment of Surgery, Oncology, and Gastroenterology, University of Padua, 35122 Padua, ItalyHepatobiliary Surgery and Liver Transplantation Unit, University of Pisa Medical School Hospital, 56126 Pisa, ItalyDepartment of Surgery, Oncology, and Gastroenterology, University of Padua, 35122 Padua, ItalyInternal Medicine, Gastroenterology and Liver Unit, A. Gemelli Polyclinic, Sacro Cuore Catholic University, 20123 Rome, ItalyDivision of Hepatobiliary and General Surgery, Department of Surgery, Humanitas Clinical and Research Center, Rozzano, 20089 Milan, ItalyDepartment of Surgery, Oncology, and Gastroenterology, University of Padua, 35122 Padua, ItalyGastroenterology Unit, Department of Internal Medicine, Università di Genova, IRCCS-Ospedale Policlinico San Martino, 16132 Genoa, ItalyAssociazione Italiana per lo Studio del Fegato (AISF), 00199 Roma, ItalyGrowing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.https://www.mdpi.com/2072-6694/11/10/1568platelet-derived growth factorvascular endothelial growth factorintegrinsselectinsplatelet-to-lymphocyte ratio |
| spellingShingle | Quirino Lai Alessandro Vitale Tommaso M. Manzia Francesco G. Foschi Giovanni B. Levi Sandri Martina Gambato Fabio Melandro Francesco P. Russo Luca Miele Luca Viganò Patrizia Burra Edoardo G. Giannini on behalf of the Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics Cancers platelet-derived growth factor vascular endothelial growth factor integrins selectins platelet-to-lymphocyte ratio |
| title | Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics |
| title_full | Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics |
| title_fullStr | Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics |
| title_full_unstemmed | Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics |
| title_short | Platelets and Hepatocellular Cancer: Bridging the Bench to the Clinics |
| title_sort | platelets and hepatocellular cancer bridging the bench to the clinics |
| topic | platelet-derived growth factor vascular endothelial growth factor integrins selectins platelet-to-lymphocyte ratio |
| url | https://www.mdpi.com/2072-6694/11/10/1568 |
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