Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer
Abstract Background Small cell lung cancer (SCLC) is highly aggressive with limited therapeutic options and a poor prognosis. Moreover, noninvasive biomarker tools for detecting disease and monitoring treatment response are lacking. To address this, we evaluated serum biomarkers of extracellular mat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-10-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.15066 |
| _version_ | 1797669391025831936 |
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| author | Jeppe Thorlacius‐Ussing Søren Risom Kristensen Morten Asser Karsdal Nicholas Willumsen Shona Pedersen |
| author_facet | Jeppe Thorlacius‐Ussing Søren Risom Kristensen Morten Asser Karsdal Nicholas Willumsen Shona Pedersen |
| author_sort | Jeppe Thorlacius‐Ussing |
| collection | DOAJ |
| description | Abstract Background Small cell lung cancer (SCLC) is highly aggressive with limited therapeutic options and a poor prognosis. Moreover, noninvasive biomarker tools for detecting disease and monitoring treatment response are lacking. To address this, we evaluated serum biomarkers of extracellular matrix proteins not previously explored in SCLC. Methods We measured biomarkers in the serum of 16 patients with SCLC before and after chemotherapy as well as in the serum of 11 healthy individuals. Results Our findings demonstrated that SCLC serum had higher levels of collagen type I degradation, collagen type III formation, and collagen type XI formation than healthy controls. In addition, we observed higher levels of type XIX and XXII collagens, fibrinogen, and von Willebrand factor A formation in SCLC serum. The formation of type I collagen did not exhibit any discernible variation. However, we observed a decrease in the degradation of type I collagen following chemotherapy. Conclusion Overall, our findings revealed elevated levels of collagen and blood‐clotting markers in the serum of SCLC patients, indicating the potential of ECM proteins as noninvasive biomarkers for SCLC. |
| first_indexed | 2024-03-11T20:43:40Z |
| format | Article |
| id | doaj.art-a76de1139bc64b588585c8bfc03c6cc9 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-11T20:43:40Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-a76de1139bc64b588585c8bfc03c6cc92023-10-01T23:26:11ZengWileyThoracic Cancer1759-77061759-77142023-10-0114282830283810.1111/1759-7714.15066Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancerJeppe Thorlacius‐Ussing0Søren Risom Kristensen1Morten Asser Karsdal2Nicholas Willumsen3Shona Pedersen4Nordic Bioscience A/S Herlev DenmarkDepartment of Clinical Medicine Aalborg University Aalborg DenmarkNordic Bioscience A/S Herlev DenmarkNordic Bioscience A/S Herlev DenmarkDepartment of Basic Medical Sciences, College of Medicine, QU Health Qatar University Doha QatarAbstract Background Small cell lung cancer (SCLC) is highly aggressive with limited therapeutic options and a poor prognosis. Moreover, noninvasive biomarker tools for detecting disease and monitoring treatment response are lacking. To address this, we evaluated serum biomarkers of extracellular matrix proteins not previously explored in SCLC. Methods We measured biomarkers in the serum of 16 patients with SCLC before and after chemotherapy as well as in the serum of 11 healthy individuals. Results Our findings demonstrated that SCLC serum had higher levels of collagen type I degradation, collagen type III formation, and collagen type XI formation than healthy controls. In addition, we observed higher levels of type XIX and XXII collagens, fibrinogen, and von Willebrand factor A formation in SCLC serum. The formation of type I collagen did not exhibit any discernible variation. However, we observed a decrease in the degradation of type I collagen following chemotherapy. Conclusion Overall, our findings revealed elevated levels of collagen and blood‐clotting markers in the serum of SCLC patients, indicating the potential of ECM proteins as noninvasive biomarkers for SCLC.https://doi.org/10.1111/1759-7714.15066biomarkerscollagenextracellular matrixsmall cell lung cancer |
| spellingShingle | Jeppe Thorlacius‐Ussing Søren Risom Kristensen Morten Asser Karsdal Nicholas Willumsen Shona Pedersen Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer Thoracic Cancer biomarkers collagen extracellular matrix small cell lung cancer |
| title | Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| title_full | Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| title_fullStr | Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| title_full_unstemmed | Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| title_short | Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| title_sort | preliminary investigation of elevated collagen and blood clotting markers as potential noninvasive biomarkers for small cell lung cancer |
| topic | biomarkers collagen extracellular matrix small cell lung cancer |
| url | https://doi.org/10.1111/1759-7714.15066 |
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