High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension.
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake. We hypothesized that a high salt intake activates the cardiac tissue renin angiotensin system and prorenin-(pro)renin receptor system, and damages th...
Main Authors: | Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4370564?pdf=render |
Similar Items
-
Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats.
by: Chihiro Okamoto, et al.
Published: (2017-01-01) -
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
by: Chiharu Yokoyama, et al.
Published: (2016-01-01) -
Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
by: Yamaki Takahiko, et al.
Published: (2012-08-01) -
Nonproteolytic activation of prorenin by the (pro)renin receptor is blocked by decoy peptide
by: Fumiaki Suzuki
Published: (2007-06-01) -
Measurement of bioactive renin concentration and renin activity in the presence of exogenous renin substrate: effect of the oral direct renin inhibitor aliskiren
by: Erik Frandsen, et al.
Published: (2008-03-01)