High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension.

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension.

It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake. We hypothesized that a high salt intake activates the cardiac tissue renin angiotensin system and prorenin-(pro)renin receptor system, and damages th...

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Bibliographic Details
Main Authors: Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370564?pdf=render

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