Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers
Background: Metabolic syndrome (MetS) has been associated with various chronic diseases that may lead to long-term sickness absence (LTSA), but there is lacking information on the direct association between MetS and LTSA. The present study aimed to investigate the all-cause and cause-specific associ...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2023-06-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/33/6/33_JE20210185/_pdf |
| _version_ | 1797809180823781376 |
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| author | Dong V. Hoang Shamima Akter Yosuke Inoue Keisuke Kuwahara Ami Fukunaga Zobida Islam Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Toshiaki Miyamoto Takayuki Ogasawara Naoko Sasaki Akihiko Uehara Makoto Yamamoto Takeshi Kochi Masafumi Eguchi Taiki Shirasaka Makiko Shimizu Satsue Nagahama Ai Hori Teppei Imai Akiko Nishihara Kentaro Tomita Chihiro Nishiura Maki Konishi Isamu Kabe Kenya Yamamoto Tetsuya Mizoue Seitaro Dohi |
| author_facet | Dong V. Hoang Shamima Akter Yosuke Inoue Keisuke Kuwahara Ami Fukunaga Zobida Islam Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Toshiaki Miyamoto Takayuki Ogasawara Naoko Sasaki Akihiko Uehara Makoto Yamamoto Takeshi Kochi Masafumi Eguchi Taiki Shirasaka Makiko Shimizu Satsue Nagahama Ai Hori Teppei Imai Akiko Nishihara Kentaro Tomita Chihiro Nishiura Maki Konishi Isamu Kabe Kenya Yamamoto Tetsuya Mizoue Seitaro Dohi |
| author_sort | Dong V. Hoang |
| collection | DOAJ |
| description | Background: Metabolic syndrome (MetS) has been associated with various chronic diseases that may lead to long-term sickness absence (LTSA), but there is lacking information on the direct association between MetS and LTSA. The present study aimed to investigate the all-cause and cause-specific associations between MetS and the risk of medically certified LTSA among Japanese workers. Methods: We recruited 67,403 workers (57,276 men and 10,127 women), aged 20–59 years from 13 companies in Japan during their health check-ups in 2011 (11 companies) and 2014 (2 companies), and we followed them for LTSA events (≥30 consecutive days) until March 31, 2020. MetS was defined according to the Joint Interim Statement. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and its 95% confidence intervals (CIs) for LTSA associated with MetS and its components. Results: During 408,324 person-years of follow-up, 2,915 workers experienced LTSA. The adjusted HR for all-cause LTSA was 1.54 (95% CI, 1.41–1.68) among those with MetS compared to those without MetS. In cause-specific analysis, HRs associated with MetS significantly increased for LTSA due to overall physical disorders (1.76); cardiovascular diseases (3.16); diseases of the musculoskeletal system and connective tissue (2.01); cancers (1.24); obesity-related cancers (1.35); mental, behavioral, and neurodevelopmental disorders (1.28); reaction to severe stress and adjustment disorders (1.46); and external causes (1.46). The number of MetS components were also significantly associated with increased LTSA risk. Conclusion: MetS was associated with an increase in the risk of LTSA due to various diseases among Japanese workers. |
| first_indexed | 2024-03-13T06:48:39Z |
| format | Article |
| id | doaj.art-a77006b13de84a69905155498502e336 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-03-13T06:48:39Z |
| publishDate | 2023-06-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-a77006b13de84a69905155498502e3362023-06-08T02:04:58ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922023-06-0133631132010.2188/jea.JE20210185Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese WorkersDong V. Hoang0Shamima Akter1Yosuke Inoue2Keisuke Kuwahara3Ami Fukunaga4Zobida Islam5Tohru Nakagawa6Toru Honda7Shuichiro Yamamoto8Hiroko Okazaki9Toshiaki Miyamoto10Takayuki Ogasawara11Naoko Sasaki12Akihiko Uehara13Makoto Yamamoto14Takeshi Kochi15Masafumi Eguchi16Taiki Shirasaka17Makiko Shimizu18Satsue Nagahama19Ai Hori20Teppei Imai21Akiko Nishihara22Kentaro Tomita23Chihiro Nishiura24Maki Konishi25Isamu Kabe26Kenya Yamamoto27Tetsuya Mizoue28Seitaro Dohi29Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanHitachi Health Care Center, Hitachi, Ltd., Ibaraki, JapanMitsui Chemicals, Inc., Tokyo, JapanNippon Steel Corporation, East Nippon Works, Chiba, JapanMitsubishi Fuso Truck and Bus Corporation, Kanagawa, JapanMitsubishi Fuso Truck and Bus Corporation, Kanagawa, JapanHidaka Tokushukai Hospital, Hokkaido, JapanYamaha Corporation, Shizuoka, JapanFurukawa Electric Co., Ltd., Tokyo, JapanFurukawa Electric Co., Ltd., Tokyo, JapanFurukawa Electric Co., Ltd., Tokyo, JapanEast Japan Works (Keihin), JFE Steel Corporation, Kanagawa, JapanAll Japan Labour Welfare Foundation, Tokyo, JapanDepartment of Global Public Health, Faculty of Medicine, University of Tsukuba, Ibaraki, JapanOH Support, Kanagawa, JapanAzbil Corporation, Tokyo, JapanHealthplant Co., Ltd., Tokyo, JapanTokyo Gas Co., Ltd., Tokyo, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanKubota Corporation, Tokyo, JapanDivision of Chemical Information, National Institute of Occupational Safety and Health, Kanagawa, JapanDepartment of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, JapanMitsui Chemicals, Inc., Tokyo, JapanBackground: Metabolic syndrome (MetS) has been associated with various chronic diseases that may lead to long-term sickness absence (LTSA), but there is lacking information on the direct association between MetS and LTSA. The present study aimed to investigate the all-cause and cause-specific associations between MetS and the risk of medically certified LTSA among Japanese workers. Methods: We recruited 67,403 workers (57,276 men and 10,127 women), aged 20–59 years from 13 companies in Japan during their health check-ups in 2011 (11 companies) and 2014 (2 companies), and we followed them for LTSA events (≥30 consecutive days) until March 31, 2020. MetS was defined according to the Joint Interim Statement. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and its 95% confidence intervals (CIs) for LTSA associated with MetS and its components. Results: During 408,324 person-years of follow-up, 2,915 workers experienced LTSA. The adjusted HR for all-cause LTSA was 1.54 (95% CI, 1.41–1.68) among those with MetS compared to those without MetS. In cause-specific analysis, HRs associated with MetS significantly increased for LTSA due to overall physical disorders (1.76); cardiovascular diseases (3.16); diseases of the musculoskeletal system and connective tissue (2.01); cancers (1.24); obesity-related cancers (1.35); mental, behavioral, and neurodevelopmental disorders (1.28); reaction to severe stress and adjustment disorders (1.46); and external causes (1.46). The number of MetS components were also significantly associated with increased LTSA risk. Conclusion: MetS was associated with an increase in the risk of LTSA due to various diseases among Japanese workers.https://www.jstage.jst.go.jp/article/jea/33/6/33_JE20210185/_pdfsickness absencemetabolic syndromelongitudinal studyjapan |
| spellingShingle | Dong V. Hoang Shamima Akter Yosuke Inoue Keisuke Kuwahara Ami Fukunaga Zobida Islam Tohru Nakagawa Toru Honda Shuichiro Yamamoto Hiroko Okazaki Toshiaki Miyamoto Takayuki Ogasawara Naoko Sasaki Akihiko Uehara Makoto Yamamoto Takeshi Kochi Masafumi Eguchi Taiki Shirasaka Makiko Shimizu Satsue Nagahama Ai Hori Teppei Imai Akiko Nishihara Kentaro Tomita Chihiro Nishiura Maki Konishi Isamu Kabe Kenya Yamamoto Tetsuya Mizoue Seitaro Dohi Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers Journal of Epidemiology sickness absence metabolic syndrome longitudinal study japan |
| title | Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers |
| title_full | Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers |
| title_fullStr | Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers |
| title_full_unstemmed | Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers |
| title_short | Metabolic Syndrome and the Increased Risk of Medically Certified Long-term Sickness Absence: A Prospective Analysis Among Japanese Workers |
| title_sort | metabolic syndrome and the increased risk of medically certified long term sickness absence a prospective analysis among japanese workers |
| topic | sickness absence metabolic syndrome longitudinal study japan |
| url | https://www.jstage.jst.go.jp/article/jea/33/6/33_JE20210185/_pdf |
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