Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI)
Purpose The Maternal Antecedents of Adiposity and Studying the transgenerational role of Hyperglycaemia and Insulin cohort in Bengaluru, South India, aims to understand the transgenerational role of increased circulating glucose levels or hyperglycaemia and other nutrients and psychosocial environme...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/9/e063794.full |
| _version_ | 1797356552966897664 |
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| author | Sanjay Kinra G V S Murthy Giridhara R Babu R Deepa Eunice Lobo Yamuna Ana Prafulla Shriyan N D Sindhu Maithili Karthik |
| author_facet | Sanjay Kinra G V S Murthy Giridhara R Babu R Deepa Eunice Lobo Yamuna Ana Prafulla Shriyan N D Sindhu Maithili Karthik |
| author_sort | Sanjay Kinra |
| collection | DOAJ |
| description | Purpose The Maternal Antecedents of Adiposity and Studying the transgenerational role of Hyperglycaemia and Insulin cohort in Bengaluru, South India, aims to understand the transgenerational role of increased circulating glucose levels or hyperglycaemia and other nutrients and psychosocial environment, on the risk of childhood obesity, as an early marker of chronic diseases.Participants Through this paper, we describe the baseline characteristics of the cohort participants and their children, along with plans and challenges. A total of 5694 pregnant women were screened, with 4862 (85.4%) eligible pregnant women recruited at baseline. We assessed anthropometry, Haemoglobin status, Oral Glucose Tolerance Test (OGTT), dietary practices, depressive symptoms using the Edinburgh Postnatal Depression Scale and social support in all women. Follow-up visits involved assessing anthropometry and the health profile of mothers and children.Findings to date Among 4862 eligible participants recruited, 3260 (67%) underwent OGTT, while 2962 participants completed OGTT (90.9%). During the pregnancy, 9.7% of women were obese (>90th percentile of skinfold thickness), and 14.3% had gestational diabetesmellitus. Moreover, 6.2% and 16.8% of women had symptoms suggestive of depression during pregnancy and the immediate postnatal period, respectively. We found that 3.3% of children were small for gestational age, 10.8% were large for gestational age and 9.7% of children were obese at birth.Future plans We have completed recruitment and baseline data collection in 2019, and are conducting annual follow-ups until age 4 of the participant’s children. For delineating causal pathways of childhood obesity, blood aliquots are stored in the biorepository. The study will inform policy formulation and community awareness in the prevention and control of non-communicable diseases and health promotion. |
| first_indexed | 2024-03-08T14:29:17Z |
| format | Article |
| id | doaj.art-a771d9dbcf94438bbc379d691704fb71 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-08T14:29:17Z |
| publishDate | 2022-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-a771d9dbcf94438bbc379d691704fb712024-01-12T16:05:08ZengBMJ Publishing GroupBMJ Open2044-60552022-09-0112910.1136/bmjopen-2022-063794Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI)Sanjay Kinra0G V S Murthy1Giridhara R Babu2R Deepa3Eunice Lobo4Yamuna Ana5Prafulla Shriyan6N D Sindhu7Maithili Karthik8Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, UKIIPH Hyderabad, Public Health Foundation, Hyderabad, Telangana, IndiaEpidemiology, Public Health Foundation of India, Bangalore, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaIndian Institute of Public Health, Public Health Foundation, Bangalore, Karnataka, IndiaPurpose The Maternal Antecedents of Adiposity and Studying the transgenerational role of Hyperglycaemia and Insulin cohort in Bengaluru, South India, aims to understand the transgenerational role of increased circulating glucose levels or hyperglycaemia and other nutrients and psychosocial environment, on the risk of childhood obesity, as an early marker of chronic diseases.Participants Through this paper, we describe the baseline characteristics of the cohort participants and their children, along with plans and challenges. A total of 5694 pregnant women were screened, with 4862 (85.4%) eligible pregnant women recruited at baseline. We assessed anthropometry, Haemoglobin status, Oral Glucose Tolerance Test (OGTT), dietary practices, depressive symptoms using the Edinburgh Postnatal Depression Scale and social support in all women. Follow-up visits involved assessing anthropometry and the health profile of mothers and children.Findings to date Among 4862 eligible participants recruited, 3260 (67%) underwent OGTT, while 2962 participants completed OGTT (90.9%). During the pregnancy, 9.7% of women were obese (>90th percentile of skinfold thickness), and 14.3% had gestational diabetesmellitus. Moreover, 6.2% and 16.8% of women had symptoms suggestive of depression during pregnancy and the immediate postnatal period, respectively. We found that 3.3% of children were small for gestational age, 10.8% were large for gestational age and 9.7% of children were obese at birth.Future plans We have completed recruitment and baseline data collection in 2019, and are conducting annual follow-ups until age 4 of the participant’s children. For delineating causal pathways of childhood obesity, blood aliquots are stored in the biorepository. The study will inform policy formulation and community awareness in the prevention and control of non-communicable diseases and health promotion.https://bmjopen.bmj.com/content/12/9/e063794.full |
| spellingShingle | Sanjay Kinra G V S Murthy Giridhara R Babu R Deepa Eunice Lobo Yamuna Ana Prafulla Shriyan N D Sindhu Maithili Karthik Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) BMJ Open |
| title | Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) |
| title_full | Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) |
| title_fullStr | Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) |
| title_full_unstemmed | Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) |
| title_short | Cohort profile: maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin (MAASTHI) |
| title_sort | cohort profile maternal antecedents of adiposity and studying the transgenerational role of hyperglycaemia and insulin maasthi |
| url | https://bmjopen.bmj.com/content/12/9/e063794.full |
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