MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway
Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats wit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2022.2056195 |
| _version_ | 1797681536265355264 |
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| author | Ji-Yun Li Yan Jin Yan-Min Cao Gui-Mei Wu |
| author_facet | Ji-Yun Li Yan Jin Yan-Min Cao Gui-Mei Wu |
| author_sort | Ji-Yun Li |
| collection | DOAJ |
| description | Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abilities and decreased the activity of TGF-β/Smad pathway, while TGFBR1 can reverse the role of miR-140-5p mimic in trophoblasts. |
| first_indexed | 2024-03-11T23:46:15Z |
| format | Article |
| id | doaj.art-a7720e6db3aa4186bcf8110a513fbd56 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:15Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-a7720e6db3aa4186bcf8110a513fbd562023-09-19T09:24:44ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652022-04-0141211612510.1080/10641955.2022.20561952056195MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathwayJi-Yun Li0Yan Jin1Yan-Min Cao2Gui-Mei Wu3Cangzhou Central HospitalCangzhou Central HospitalCangzhou Central HospitalCangzhou Central HospitalAnimal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved regarding the above indicators. Cell experiments demonstrated that miR-140-5p mimic increased cell invasion and migration abilities and decreased the activity of TGF-β/Smad pathway, while TGFBR1 can reverse the role of miR-140-5p mimic in trophoblasts.http://dx.doi.org/10.1080/10641955.2022.2056195mir-140-5ppregnancy-induced hypertensiontgf-β/smad pathwaytgfbr1 |
| spellingShingle | Ji-Yun Li Yan Jin Yan-Min Cao Gui-Mei Wu MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway Hypertension in Pregnancy mir-140-5p pregnancy-induced hypertension tgf-β/smad pathway tgfbr1 |
| title | MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway |
| title_full | MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway |
| title_fullStr | MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway |
| title_full_unstemmed | MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway |
| title_short | MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway |
| title_sort | mir 140 5p exerts a protective function in pregnancy induced hypertension via mediating tgf β smad signaling pathway |
| topic | mir-140-5p pregnancy-induced hypertension tgf-β/smad pathway tgfbr1 |
| url | http://dx.doi.org/10.1080/10641955.2022.2056195 |
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